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MetabolomicsThe Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have documented a plasma membrane invagination with a d...

2023-04-19 | MTBLS7006 | MetaboLights
ProteomicsA core UPS molecular complement implicates unique endocytic compartments at the parasite-host interface in Giardia lamblia – native IP conditions
Affinity purification and mass spectrometry coupled to microscopy-based subcellular localization and signal correlation quantification techniques were employed to investigate protein complexes of eleven reported unconventionally-secreted putative and confirmed virulence factors of Giardia lamblia, a...
ORGANISM(S): Giardia intestinalis assemblage A 
2022-07-15 | PXD035190 | Pride
Giardia lamblia Virulence Unconventional protein secretion Peripheral endocytic compartments Interactome 
ProteomicsA core UPS molecular complement implicates unique endocytic compartments at the parasite-host interface in Giardia lamblia – crosslinking IP conditions
Affinity purification and mass spectrometry coupled to microscopy-based subcellular localization and signal correlation quantification techniques were employed to investigate protein complexes of eleven reported unconventionally-secreted putative and confirmed virulence factors of Giardia lamblia, a...
ORGANISM(S): Giardia intestinalis assemblage A 
2022-07-15 | PXD035195 | Pride
Giardia lamblia Virulence Unconventional protein secretion Peripheral endocytic compartments Interactome 
UnknownCell-free fusion of bacteria-containing phagosomes with endocytic compartments.
Not available
S-EPMC2996438 | biostudies-literature
UnknownAPPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments.
Not available
S-EPMC4602042 | biostudies-literature
ProteomicsA selective autophagy pathway for endocytic protein condensates
Autophagy eliminates cytoplasmic content selected by autophagy receptors, which link cargoes to the membrane bound autophagosomal ubiquitin-like protein Atg8/LC3. Here, we discover a selective autophagy pathway for protein condensates formed by endocytic proteins. In this pathway, the endocytic yeas...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-11-23 | PXD019083 | Pride
Liquid-liquid phase separation Atg8 Selective autophagy Ede1 
UnknownCombined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Metamonada.
Not available
S-EPMC9490929 | biostudies-literature
UnknownThe use of fluorescence microscopy to define polymer localisation to the late endocytic compartments in cells that are targets for drug delivery.
Not available
S-EPMC6661902 | biostudies-literature
UnknownThe Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments.
Not available
S-EPMC4181540 | biostudies-literature
UnknownA core UPS molecular complement implicates unique endocytic compartments at the parasite-host interface in Giardia lamblia.
Not available
S-EPMC9928461 | biostudies-literature
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