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GenomicsSystematic discovery of endogenous human ribonucleoprotein complexes
Systematic discovery of endogenous human ribonucleoprotein complexes
PRJNA566149 | ENA
ProteomicsEndogenous brain ARC complexes
Arc is an activity regulated neuronal protein yet little is known about its protein interactions, assembly into multiprotein complexes, role in human disease and cognition. We applied an integrated proteomic and genetic strategy using targeted tagging of a Tandem Affinity Purification (TAP) tag and ...
ORGANISM(S): Mus musculus (Mouse) 
2017-10-19 | PXD007283 | Pride
Complexes Brain Mouse Lc-ms/ms 
TranscriptomicsHigh-throughput pyrosequencing of endogenous small RNAs from CSR-1 IP complexes and csr-1(tm892) and ego-1(om97) mutants
High-throughput pyrosequencing of endogenous small RNAs from CSR-1 IP complexes and csr-1(tm892) and ego-1(om97) mutants with corresponding controls. RNAi-related pathways regulate diverse processes, from developmental timing to transposon silencing. Here, we show that in C. elegans the Argonaute CS...
ORGANISM(S): Caenorhabditis elegans 
2009-10-02 | E-GEOD-18165 | biostudies-arrayexpress
TranscriptomicsCoordinated regulation of polycomb group complexes through microRNAs in cancer
To determine the altered mRNA expression signatures upon overexpressing EZH2 regulated microRNAs in cancer. To identify EZH2 regulated microRNAs in cancer. Two-condition experiment: Each EZH2 microRNA was overexpressed and compared to a control RNA in BT549 breast cancer cells. In DU145 prostate can...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-26996 | biostudies-arrayexpress
TranscriptomicsSystematic discovery of endogenous human ribonucleoprotein complexes
An exploration of human protein complexes in the presence and absence of RNA reveals endogenous ribonucleoprotein complexes
ORGANISM(S): Homo sapiens 
2019-09-19 | GSE137651 | GEO
GenomicsPCGF Homologs and RYBP Define Functionally Distinct PRC1 Family Complexes
The heterogeneous nature of mammalian PRC1 complexes has hindered our understanding of their biological functions. Here, we present a comprehensive proteomic and genomic analysis that uncovered six major groups of PRC1 complexes each containing a distinct PCGF subunit, a RING1A/B ubiquitin ligase, a...
ORGANISM(S): Homo sapiens 
2012-02-09 | E-GEOD-34774 | biostudies-arrayexpress
ProteomicsAge-related cleavages of crystallins in human lens cortical fibre cells generate a plethora of low molecular weight peptides and cross-linked crystallin complexes
A large variety of low molecular weight (LMW) peptides, derived from the breakdown of crystallins, have been reported in middle to old age human lenses. The proliferation of these LMW peptides coincides with the earliest stages of cataract formation, suggesting that the protein cleavages involved ma...
ORGANISM(S): Homo sapiens (Human) 
2016-09-29 | PXD001593 | Pride
Human lens Crystallin Endogeneuous peptideslens aging  crystallin  cataract  mass spectrometry  endogenous peptides  2-d gel electrophoresis  nanolc-esi-ms/ms  trypsin-like cleavage 
TranscriptomicsVirus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis
Virus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis This study constructed and sequenced two independent small RNA libraries from the upper uninoculated leaves of (i) WT Arabidopsis plants 14 d after mock inoculation and of (ii) rdr1 rd...
ORGANISM(S): Arabidopsis thaliana 
2014-08-30 | E-GEOD-60929 | biostudies-arrayexpress
TranscriptomicsExpression regulation by RYBP in mouse embryonic stem cells
Polycomb repressive complexes (PRCs) are important chromatin regulators of ES cell function. RYBP binds Polycomb H2A monoubiquitin ligases Ring1A and Ring1B, and has been suggested to participate in localizing Polycomb complexes to their targets. Moreover, constitutive inactivation of RYBP precludes...
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-32294 | biostudies-arrayexpress
GenomicsInterconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome.
The conserved core domain of the TATA binding protein (TBP) interacts with multiple partners forming the complexes required for transcription by RNA Polymerases I, II and III. We use genetically modified mouse embryonic fibroblasts to show that many TBP core domain mutants complement loss of endogen...
ORGANISM(S): Mus musculus 
2012-03-01 | E-GEOD-27908 | biostudies-arrayexpress
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