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ProteomicsAnalysis of mouse lens morphological and proteomic abnormalities following depletion of the betaB3-crystallin
Crystallin proteins serve as both essential structural and protective components of the ocular lens required for its transparency and light refraction. The mouse lens crystallin proteome is represented by alphaA-, alphaB-, betaA1-, betaA2-, betaA3-, betaA4-, betaB1-, betaB2-, betaB3-, gammaA-, gamma...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-01 | PXD059220 | Pride
Cytoplasm Isobaric labeling Cataract Proteomes Betab3-crystallin Lens Quantitative proteomics 
ProteomicsAge-related cleavages of crystallins in human lens cortical fibre cells generate a plethora of low molecular weight peptides and cross-linked crystallin complexes
A large variety of low molecular weight (LMW) peptides, derived from the breakdown of crystallins, have been reported in middle to old age human lenses. The proliferation of these LMW peptides coincides with the earliest stages of cataract formation, suggesting that the protein cleavages involved ma...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081536 | MassIVE
TranscriptomicsYeast zeta-crystallin: An AU-Rich Element Binding Protein Involved in the Nutritional Stress Response
The yeast M-NM-6-crystallin Zta1p interacts specifically with RNA sequences rich in adenine and uracil (AU-rich element). We have looked for possible targets of Zta1p through a comparative transcriptional analysis of the yeast defective in ZTA1 (M-NM-^Tzta1) versus the wild-type by microarray. This ...
ORGANISM(S): Saccharomyces cerevisiae 
2015-02-27 | E-GEOD-45297 | biostudies-arrayexpress
ProteomicsThe structure and oxidation of the eye lens chaperone αA-crystallin
Structural impact of the intramolecular disulfide bond on human αA-crystallin
ORGANISM(S): Homo sapiens (Human) 
2019-10-07 | PXD013587 | Pride
Domain swapping Cryo-electron microscopy Αa-crystallin Small heat shock protein Disulfide bond 
TranscriptomicsRegulation of the Mycobacterium tuberculosishypoxic response gene encoding alpha-crystallin
Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic condit...
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-05 | E-GEOD-8639 | biostudies-arrayexpress
GenomicsMurine lenses:βB2-crystallin W151C knock-in mice vs.wild type control mice
Murine lenses:βB2-crystallin W151C knock-in mice vs.wild type control mice
PRJNA936163 | ENA
ProteomicsThe small heat shock protein Alpha-Crystallin B shows neuroprotective properties in a glaucoma animal model
Aim of this study was the evaluation of Alpha-crystallin B and its potential neuroprotective properties in an experimentalanimal model of glaucoma with subsequent analysis of possible altered downstream markers in a complex mass spectrometric approach.
ORGANISM(S): Rattus norvegicus (Rat) 
2017-11-21 | PXD007751 | Pride
Experimental glaucoma  alpha-crystallin b  neuroprotection  proteomics 
GenomicsLoss of striatal astrocyte u-crystallin (Crym) contributes to early stage Huntington’s disease pathophysiology
Loss of striatal astrocyte u-crystallin (Crym) contributes to early stage Huntington’s disease pathophysiology
PRJNA1470990 | ENA
ProteomicsThe small heat shock protein Alpha-Crystallin B shows neuroprotective properties in a glaucoma animal model
Aim of this study was the evaluation of Alpha-crystallin B and its potential neuroprotective properties in an experimentalanimal model of glaucoma with subsequent analysis of possible altered downstream markers in a complex mass spectrometric approach.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2017-11-28 | MSV000081755 | MassIVE
ProteomicsPrognostic value of biomarkers EpCAM and B-crystallin is associated with lymphatic metastasis in breast cancer by iTRAQ analysis
Metastasis is responsible for the majority of deaths in a variety of cancer types, including breast cancer. Although several factors or biomarkers have been identified to predict the outcome of patients with breast cancer, few studies have been conducted to identify metastasis-associated biomarkers....
ORGANISM(S): Homo sapiens (Human) 
2019-08-29 | PXD013931 | Pride
Breast cancer  metastasis  epcam  fadd  ndrg1  αb-crystallin  biomarker  itraq proteomic analysis 
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