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MetabolomicsPolystyrene nanoparticles promote endometrial cancer development through the ACSS2-mediated reprogramming of arachidonic acid metabolism

Microplastics and nanoplastics are commonly found in our everyday environments. So far, microplastics and nanoplastics have been detected in various tissues and bodily fluids, including hair, sputum, digestive tissue, lungs, blood, and placental tissue. Although some studies indicate that micropl...

2026-02-05 | MTBLS13850 | MetaboLights
ProteomicsRole of prorenin receptor (P)RR in endometrial cancer cell growth
Endometrial cancer is the most commonly diagnosed gynecologic malignancy in women after breast, lung and colorectal cancer. Despite numerous scientific advances, the incidence and mortality rate of endometrial cancer is on the rise. Considerable research effort has therefore been placed on understan...
ORGANISM(S): Homo sapiens (Human) 
2022-04-23 | PXD023042 | Pride
Quantitative proteomics Endometrial epithelial cancer cell Cellular proliferation Tandem mass tags An3ca and hec-1a Atp6ap2 (p)rr Ishikawa Cellular viability 
TranscriptomicsRNA-seq of human endometrial cancer cell line Ishikawa treated with BMP2
To elucidate the biological function of BMP2 in endometrial cancer cells, Ishikawa, a human endometrial cancer cell line, was stimulated with BMP2 for indicated hours.
ORGANISM(S): Homo sapiens 
2021-09-30 | E-MTAB-10275 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of endometrial epithelial cells (EECs) to understand actions of tamoxifen in the uterus and its molecular effectors in endometrial carcinogenesis
The molecular explanation for tamoxifen serving as a breast cancer treatment but displaying partial estrogenic in the uterus is not known. Previously, we reported that differential promoter context and cofactor recruitment contribute to the tissue specificity of tamoxifen. Here, we investigated the ...
ORGANISM(S): Homo sapiens 
2007-09-08 | E-GEOD-3013 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of Stage I Endometrial Cancers
Global gene expression patterns associated with early stage endometrial cancer have been reported, but changes in molecular expression associated with tumor grade, depth of myometrial invasion, and non-endometrioid histology have not been previously elucidated. Our group hypothesized there are uniq...
ORGANISM(S): Homo sapiens 
2011-12-13 | E-GEOD-17025 | biostudies-arrayexpress
ProteomicsAltered N-linked Glycosylation in Endometrial Cancer
It has been recognised for a long time that cell surface glycans plays a vital role in the biological process and their altered form can lead to cancer. However, the molecular details and regulatory mechanism between the glycans and cancer is yet not clear. Over the past decade mass spectrometry-bas...
ORGANISM(S): Homo sapiens (Human) 
2020-11-27 | PXD019425 | Pride
Biomarker Lymph node metastasis Endometrial cancer Glycan imaging 
TranscriptomicsProgesterone inhibits epithelial-to-mesenchymal transition in endometrial cancer
This SuperSeries is composed of the following subset Series: GSE29435: Progesterone inhibits epithelial-to-mesenchymal transition in endometrial cancer: cell line data GSE29436: Progesterone inhibits epithelial-to-mesenchymal transition in endometrial cancer: patient data Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-01-26 | E-GEOD-29437 | biostudies-arrayexpress
MetabolomicsProfiling the metabolome of uterine fluid for early detection of ovarian cancer

Ovarian cancer (OC) causes high mortality in women because of ineffective biomarkers for early diagnosis. Here, we perform metabolomics analysis on an initial training set of uterine fluid from 96 gynecological patients. A seven-metabolite-marker panel consisting of vanillylmandelic acid, norepin...

2023-03-06 | MTBLS4861 | MetaboLights
TranscriptomicsCOUP-TFII regulates human endometrial stromal genes involved in inflammation
Although the function of COUP-TFII in uterine decidualization has been described in mice, its role in the human uterus remains unknown.To interrogate the role of COUP-TFII in human endometrial function, we utilized a siRNA-mediated loss of function approach in primary human endometrial stromal cells...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-47052 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of Endometrial organoids treated with NOTCH or WNT inhibitors in a time course of Estrogen and Progesterone stimulation
We performed single-cell RNA-sequencing of 3D endometrial organoid cultures in order to dissect the signaling pathways that determine cell fate of epithelial lineages. Every time course was obtained in a background that either included or did not include ovarian hormones stimulation, which emulates ...
ORGANISM(S): Homo sapiens 
2021-07-21 | E-MTAB-10283 | biostudies-arrayexpress
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