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TranscriptomicsDifferential expression of Wnt signalling molecules between pre- and post-menopausal endometrial epithelial cells suggests that a population of putative epithelial stem/progenitor cells reside in the basalis layer
The human endometrium is a highly regenerative tissue that undergoes cyclical proliferation, differentiation and shedding each month. The upper functionalis layer of the endometrium is shed in response to circulating levels of estrogen and progesterone, while the lower basalis layer remains. Clonoge...
ORGANISM(S): Homo sapiens 
2012-04-10 | E-GEOD-35221 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of Stage I Endometrial Cancers
Global gene expression patterns associated with early stage endometrial cancer have been reported, but changes in molecular expression associated with tumor grade, depth of myometrial invasion, and non-endometrioid histology have not been previously elucidated. Our group hypothesized there are uniq...
ORGANISM(S): Homo sapiens 
2011-12-13 | E-GEOD-17025 | biostudies-arrayexpress
TranscriptomicsDeep Sequencing of the Porcine Endometrial Transcriptome on Day 14 of Pregnancy
In pigs, conceptus attachment to the uterine surface epithelium starts around day 14 of pregnancy preceded by a pronounced vascularization at the implantation zones, initiating the epitheliochorial placentation. To characterize the complex transcriptome changes in the endometrium in the course of in...
ORGANISM(S): Sus scrofa 
2013-03-07 | E-GEOD-43667 | biostudies-arrayexpress
TranscriptomicsETV5 transcription program links BDNF and promotion of EMT at invasive front of endometrial carcinomas.
We have characterized the transcriptional program regulated by ETV5 at the invasive front of endometrial carcinomas, by comparing it with non-invasive areas of the same tumor samples. In total 12 samples; 6 superficial (non-invasive) tumor areas and the corresponding invasive tumor zones.
ORGANISM(S): Homo sapiens 
2014-11-05 | E-GEOD-57870 | biostudies-arrayexpress
ProteomicsThe tumour-derived extracellular vesicle proteome varies by endometrial cancer histology and is confounded by an obesogenic environment
Endometrial cancer is the most prevalent gynaecological cancer globally. Its association with obesity and metabolic diseases is a key aetiology, increasingly among younger females. Early diagnosis and improved treatment decisions are crucial for these individuals which could be fulfilled by the disc...
ORGANISM(S): Homo sapiens (Human) 
2024-09-24 | PXD045074 | Pride
Swath Biomarkers Extracellular vesicles Endometrial cancer Secretome 
TranscriptomicsBovine pre-transfer endometrium and embryo transcriptome fingerprints as predictors of pregnancy success after embryo transfer (endometrial study)
The aberrant gene expression in the uterine endometrium and embryo has been the major causes of pregnancy failure in cattle. Therefore, selecting cows having adequate endometrial receptivity and embryos of better developmental competence based on the gene expression could increase the number of calv...
ORGANISM(S): Bos taurus 
2010-04-07 | E-GEOD-20974 | biostudies-arrayexpress
GenomicsAging affects ciliated cells development in human endometrial epithelium
Aging affects ciliated cells development in human endometrial epithelium
PRJNA989112 | ENA
ProteomicsPlasma membrane proteome of adhesion-competent endometrial epithelial cells and its modulation by Rab11a
Human endometrial epithelium (EE) is composed of a multitude of proteins, amongst which those localized on the plasma membrane (plasma membrane proteins-PMPs) are of critical relevance in early stages of implantation. Evidences support the key role of few PMPs in implantation. However, many remain u...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD015010 | Pride
Epithelium Plasma membrane Ishikawa Proteomics Endometrium 
TranscriptomicsEffects of high concentrations of progesterone and Mifepristone: a gene expression study of endometrial cancer cells
Patients with endometrial hyperplasia representing preliminary stages of endometrial cancer have shown to respond to therapy in 100% of the cases when treated with levonorgestrel -impregnated intrauterine device. Antiproliferative effect has also been reported after application of an anti-progestin ...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-14713 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of rat endometrial cancer
Transcriptional profiling of rat EAC - comparison of non-/pre-malignant endometrium with endometrial tumors Endometrial cancer develops from the endometrium of the uterus and is the most common pelvic malignancy diagnosed in women in the western countries. Similar to all cancer diseases, endometrial...
ORGANISM(S): Rattus norvegicus 
2010-05-19 | E-GEOD-13003 | biostudies-arrayexpress
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