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MetabolomicsSpatiotemporal determination of metabolite activities in the corneal epithelium on a chip
The corneal epithelial barrier maintains the metabolic activities of the ocular surface by regulating membrane transporters and metabolic enzymes responsible for the homeostasis of the eye as well as the pharmacokinetic behavior of drugs. Despite its importance, no established biomimetic in vitro me...
2021-07-13 | MTBLS2274 | MetaboLights
MetabolomicsComparative metabolomics analysis of bronchial epithelium during barrier establishment after allergen exposure

BACKGROUND: Several studies have shown a correlation between an altered metabolome and respiratory allergies. The epithelial barrier hypothesis proposes that an epithelial barrier dysfunction can result in allergic diseases development. Der p 1 allergen from house dust mite is a...

2023-08-22 | MTBLS1755 | MetaboLights
MetabolomicsUntargeted metabolomics profiling of intestinal epithelium-specific PCK1 knockout mice and littermate controls

Metabolic dysregulation may serve as a pivotal driver of inflammatory bowel disease, with the crosstalk between metabolism and the immune system emerging as a critical research focus. Ulcerative colitis patients exhibit enhanced glycolysis but suppressed ...

2026-06-24 | MTBLS12440 | MetaboLights
TranscriptomicsTranscription profiling of murine olfactory epithelium during neuronal death and replacement to study adult neurogenesis in the olfactory epithelium
Expression profiling of mRNA abundance in the adult mouse olfactory epithelium during replacement of OSNs forced by the bilateral ablation of the olfactory bulbs. The experiment was done on 6 week old male C57Bl/6 mice. Olfactory epithelium tissue samples were collected on days 1, 5, and 7 after b...
ORGANISM(S): Mus musculus 
2007-09-04 | E-GEOD-2437 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse small intestinal epithelium at different development stages (E18.5, P7, P21)
To assess the role of genes in development in mouse small intestinal epithelium, we isolated intestinal epithelium tissue from wild type mice at E18.5, P7 and P21. RNA was directly isolated used for RNA seq and were able to investigate gene expression at different development stages
ORGANISM(S): Mus musculus 
2020-11-16 | E-MTAB-8713 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse olfactory epithelium frpm Harlequin mutants compared to littermate controls
Microarray analysis of gene expression in the olfactory epithelium of Harlequin mouse as a model of oxidative-stress induced neurodegeneration of olfactory sensory neurons Experiment Overall Design: Olfactory epithelium from Harlequin mutant mice and littermate control mice was microdissected for RN...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6485 | biostudies-arrayexpress
GenomicsH3K4me1 ChIP-seq of mouse small intestinal epithelium at different development stages (E18.5, P7, P21)
To assess the role of H3K4me1 in development in mouse small intestinal epithelium, we isolated intestinal epithelium tissue from wild type mice at E18.5, P7 and P21. This tissue was digested to single cells, sorted, fixed, isolated chromatin, and performed ChIP using an H3K4me1 antibody as described...
ORGANISM(S): Mus musculus 
2020-11-16 | E-MTAB-8710 | biostudies-arrayexpress
Proteomicscryo-EM study of bovine retinal pigment epithelium cell lysate
This is the proteomic analysis data of bovine retinal pigment epithelium cell lysate subjected to cryo-EM study.
ORGANISM(S): Bos taurus (Bovine) 
2023-01-02 | PXD037186 | Pride
Cryo-em Bovine Retinal pigment epithelium cell 
TranscriptomicsGene regulation by Sox9 in the conjunctival epithelium
Wild type or Sox9 fx/fx; Le-Cre-positive (Sox9-/-) conjunctival epithelium from the temporal, nasal and dorsal region of E14.5 mouse embryos was laser micodissected from three embryos of each genotype. Total RNA was purified and reverse transcribed and amplified using a NuGEN kit. cDNA was biotinyla...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-54796 | biostudies-arrayexpress
ProteomicsThe proteome of normal human iris, ciliary body, retinal pigment epithelium, and choroid
The iris is a fine structure that controls the amount of light that enters the eye. The ciliary body controls the shape of the lens and produces aqueous humor. The retinal pigment epithelium and choroid (RPE/choroid) are essential in supporting the retina and absorbing light energy that enters the e...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-29 | MSV000081766 | MassIVE
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