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Post-partum uterine inflammation (endometritis) is associated with lower fertility at both the time of infection and after the inflammation has resolved. It was hypothesized that aberrant DNA methylation may be involved in the sub-fertility associated with post-partum uterine inflammation. The objec...
ORGANISM(S): Bos taurus 
Uterine fluid (UF) samples were acquired from healthy cows, cows with clinical (CLE) and subclinical endometritis (SE). The extracellular vesicles (EVs) were isolated using size exclusion chromatography-based method. The enrichment of UF-EVs were confirmed with mass-spectrometry of a sample before a...
ORGANISM(S): Bos taurus (Bovine) 
2026-04-27 | PXD044219 | Pride
The study collected eight mares with chronic endometritis and eight healthy mares, respectively. In LC-MS analysis, the DDA method was employed to identify quantitatively differential proteins.
ORGANISM(S): Equus caballus (Horse) 
2024-03-14 | PXD047408 | Pride
Role of SREBP1 in chronic endometritis
A total of 1180 proteins were identified in the control group and endometritis model group, of which 313 differential proteins were accurately quantified. The proteomic results were verified by WB, TEC and IF techniques, and the same conclusion was obtained.
ORGANISM(S): Capra Hircus 
2022-05-18 | PXD033950 |
Clinical or subclinical endometritis could affect the cow fertility by disturbing the molecular milieu of the uterine environment. We used a global gene expression approach to understand the effect of clinical and subclinical endometritis on endometrial transcriptome profiles of cows
ORGANISM(S): Bos taurus 
2016-11-13 | GSE74987 | GEO
The regulation of endometrial inflammation has important consequences for the resumption of bovine fertility post-partum. All cows experience bacterial influx into the uterus after calving; however a significant proportion fail to clear infection leading to the development of cytological endometriti...
ORGANISM(S): Bos taurus 
Endometrial microbiota in infertile women with and without chronic endometritis
Post-partum uterine inflammation (endometritis) is associated with lower fertility at both the time of infection and after the inflammation has resolved. It was hypothesized that aberrant DNA methylation may be involved in the sub-fertility associated with post-partum uterine inflammation. The objec...
ORGANISM(S): Bos taurus 
The aim of this study was to investigate the role of SREBP1a in the regulation of inflammation in endometrial tissue after LPS injection. We report that systemic deletion of Srebf1, which encodes SREBP1, resulted in persistent endometrial inflammation and CD138-positive plasma cell infiltration. In ...
ORGANISM(S): Mus musculus 
2025-05-08 | GSE278134 | GEO
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