Sort   by:  
 Page size 
ProteomicsLNP formulations for efficient hepatic delivery studied with an in-vivo endosomal escape assay
Endosomal escape is a central barrier to efficient nucleic acid delivery by lipid nanoparticles (LNPs) and remains challenging to quantify in vivo. We report a library of branched ionizable phospholipids (BiPs) that markedly enhance mRNA delivery to the liver. The lead candidate BiP-20 outperformed ...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-20 | PXD072066 | Pride
Lipid nanoparticle Mass spectrometry Endosomal escape Quantitative proteomics Gene editing 
UnknownDesign rules for efficient endosomal escape.
Not available
S-EPMC10635116 | biostudies-literature
UnknownEndosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale.
Not available
S-EPMC8666849 | biostudies-literature
UnknownHOPS-Dependent Endosomal Escape Demands Protein Unfolding.
Not available
S-EPMC11046473 | biostudies-literature
UnknownImaging small molecule-induced endosomal escape of siRNA.
Not available
S-EPMC7156650 | biostudies-literature
UnknownQuantitating Endosomal Escape of a Library of Polymers for mRNA Delivery.
Not available
S-EPMC7195212 | biostudies-literature
UnknownLimiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape.
Not available
S-EPMC12352612 | biostudies-literature
UnknownEvaluating Endosomal Escape of Caspase-3-Containing Nanomaterials Using Split GFP.
Not available
S-EPMC8477791 | biostudies-literature
UnknownEnhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics.
Not available
S-EPMC5015074 | biostudies-literature
UnknownIlluminating endosomal escape of polymorphic lipid nanoparticles that boost mRNA delivery.
Not available
S-EPMC8769212 | biostudies-literature
Sort   by:  
 Page size