Endosomal trafficking

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UNIPROT ID/AC

P60568 (1)
P14784 (1)
P31785 (1)

Metabolite Name

TG(20:0_18:1_22:6) (1)
TG(18:0_20:1_20:4) (1)
TG(18:0_18:2_22:3) (1)
TG(18:0_18:1_24:5) (1)
TG(17:1_18:1_24:1) (1)
TG(17:0_18:1_20:1) (1)
TG(16:1_18:1_26:2) (1)
TG(16:1_17:1_24:1) (1)
TG(16:0_16:0_24:0) (1)
TG(14:0_16:0_22:0) (1)
SHexCer(d18:1/16:0(OH)) (1)
HexCer(t18:2/20:0(2OH)) (1)
HexCer(d18:2/20:0) (1)
HexCer(d18:2/18:0) (1)
HexCer(d18:1/26:1) (1)
HexCer(d18:1/17:0) (1)
HexCer(d16:1/24:0) (1)
HexCer(d16:1/20:0) (1)
DG(12:0_16:1) (1)
DG(12:0_16:0) (1)
Cer(t19:2/18:2(2OH)) (1)
Cer(t17:2/22:1) (1)
Cer(t17:2/16:1) (1)
Cer(t17:1/22:2) (1)
Cer(d18:2/15:0(2OH)) (1)
Cer(d18:1/22:2(2OH)) (1)
Cer(d18:1/19:1(2OH)) (1)
Cer(d17:1/22:0) (1)
Cer(d17:1/15:1(2OH)) (1)
SM(d18:1/21:1) (1)

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2024 (10)
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Modelling Approach

Ordinary differential equation model (1)

Study type

Transcription profiling by array (3)
Other (1)

Release Date

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2019 (93)
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Lab affiliation

School of Life Sciences, University of Warwick (9)
German Center for Neurodegenerative Diseases Munich, Neuroproteomics, Feodor-Lynen Str. 17, D-81377 Munich, Germany (2)
School of Biochemistry Faculty of Life Sciences University of Bristol (2)
Faculté de Médecine et des Sciences de la Santé Department of Immunology and Cell Biology Université de Sherbrooke (1)
Epithelial Systems Biology Laboratory Systems Biology Center Division of Intramural Research NHLBI, NIH USA (1)
Department of Cell and Chemical Biology at the Leiden University Medical Center. (1)
Lab Head Proteomics Unit - CNIC - Madrid, Spain (1)
1) Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA 2) Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA 3) Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA (1)
Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany Current address: Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany (1)
Cell Biology Department, Harvard Medical School (1)
The Sainsbury Laboratory, Proteomics group, Norwich, UK (1)
Department of Chemical Physiology and Biochemistry Oregon Health & Science University 3181 SW Sam Jackson Park Road, Mail Code L-334, Portland, OR, 97239, USA (1)
Department of Proteomics and Signal Transduction, Systems Biology of Membrane Trafficking Research Group, Max-Planck Institute of Biochemistry, Martinsried, Germany (1)
université de sherbrooke (1)
Institute of Biochemistry II, University Hospital, Goethe University, Frankfurt, Germany (1)
Institute of Clinical Chemistry, University Medical Center Goettingen, Goettingen/Germany (1)
CNRS UMR 7178 IPHC-DSA-LSMBO (1)
Academia Sinica,Institute of Biological Chemistry (1)
Department of Molecular and Applied Microbiology, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Adolf-Reichwein-Str. 23, D-07745 Jena, Germany (1)
IGMM, University of Edinburgh (1)
Harvard T. H. Chan School of Public Health (1)
Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology (1)
Department of Pharmaceutical Sciences Oregon State University College of Pharmacy Portland, OR 97301 USA (1)
Department of Biochemistry and Pharmacology, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, 3052, Australia. (1)
Dept of Immunology and Oncology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus UAM Cantoblanco, 28079 Madrid, Spain (1)
Department of Biochemistry and Molecular Biology, Infection and Immunity theme, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia (1)
1- i3S - Instituto de Investigação e Inovação em Saúde,Universidade do Porto, Portugal 2- IBMC - Instituto de Biologia Celular e Molecular, Universidade do Porto, Portugal 3- ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal (1)
Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany (1)
Queen's University Belfast (1)
1- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal 2- IBMC - Instituto de Biologia Celular e Molecular, Universidade do Porto, Portugal 3- ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal (1)

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Ceramide Disrupts TM9SF2-PGK1 Axis to Redirect PD-L1 Trafficking and Enhance Antitumor Immunity

The PD-1/PD-L1 axis represents a cornerstone of cancer immunotherapy, yet the dynamic shuttling of PD-L1 between endosomal recycling and lysosomal degradation routes limits durable responses. Using a CRISPR screen targeting glycosphingolipid metabolism, we identify TM9SF2 as a key regulator of PD...

2026-02-05 | MTBLS13838 | MetaboLights

Endosomal trafficking bypassed by RAB5B-CD109 interplay promotes axonogenesis in KRAS-mutant pancreatic cancer

PRJNA1055921 | ENA

Endosomal sorting regulates PD-L1 trafficking and enhances immunotherapy efficacy

Immune-checkpoint inhibition affecting the PD-1/PD-L1 pathway is a robust clinical approach to treat cancer. Unfortunately, antibody-binding-caused PD-L1 internalization and recycling can lead to resistance and reduced clinical efficacy. Inhibiting lysosome-mediated PD-L1 degradation is necessary to...

ORGANISM(S): Homo sapiens (Human)

2026-06-08 | PXD061780 | Pride