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MetabolomicsCeramide Disrupts TM9SF2-PGK1 Axis to Redirect PD-L1 Trafficking and Enhance Antitumor Immunity

The PD-1/PD-L1 axis represents a cornerstone of cancer immunotherapy, yet the dynamic shuttling of PD-L1 between endosomal recycling and lysosomal degradation routes limits durable responses. Using a CRISPR screen targeting glycosphingolipid metabolism, we identify TM9SF2 as a key regulator of PD...

2026-02-05 | MTBLS13838 | MetaboLights
ProteomicsEndosomal sorting regulates PD-L1 trafficking and enhances immunotherapy efficacy
Immune-checkpoint inhibition affecting the PD-1/PD-L1 pathway is a robust clinical approach to treat cancer. Unfortunately, antibody-binding-caused PD-L1 internalization and recycling can lead to resistance and reduced clinical efficacy. Inhibiting lysosome-mediated PD-L1 degradation is necessary to...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD061780 | Pride
Immune checkpoint inhibitor Pgk1 Endosomal sorting Tm9sf2 Ceramide Pd-l1 Immunotherapy 
ProteomicsCeramide Disrupts TM9SF2-PGK1 Axis to Redirect PD-L1 Trafficking and Enhance Antitumor Immunity
The programmed cell death protein 1 (PD-1) / programmed death-ligand 1 (PD-L1) axis represents a cornerstone of cancer immunotherapy, yet the dynamic shuttling of PD-L1 between endosomal recycling and lysosomal degradation routes limits durable responses. Using a CRISPR screen targeting glycosphingo...
ORGANISM(S): Homo Sapiens 
2026-02-27 | PXD075012 |
GenomicsTM9SF2 Reprograms Antigen Presenting Neutrophils to Overcome Immune Evasion in NSCLC
TM9SF2 Reprograms Antigen Presenting Neutrophils to Overcome Immune Evasion in NSCLC
PRJNA1304920 | ENA
UnknownTM9SF2 Maintains Golgi Integrity and Regulates Ricin-Induced Cytotoxicity.
Not available
S-EPMC12116000 | biostudies-literature
GenomicsTM9SF2 Reprograms Antigen Presenting Neutrophils to Overcome Immune Evasion in NSCLC [scRNA-seq]
TM9SF2 Reprograms Antigen Presenting Neutrophils to Overcome Immune Evasion in NSCLC [scRNA-seq]
PRJNA1303212 | ENA
UnknownTransposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene.
Not available
S-EPMC6193042 | biostudies-literature
GenomicsTM9SF2 Reprograms Antigen Presenting Neutrophils to Overcome Immune Evasion in NSCLC [Bulk RNA-seq]
TM9SF2 Reprograms Antigen Presenting Neutrophils to Overcome Immune Evasion in NSCLC [Bulk RNA-seq]
PRJNA1303213 | ENA
UnknownLINC01232 exerts oncogenic activities in pancreatic adenocarcinoma via regulation of TM9SF2.
Not available
S-EPMC6754375 | biostudies-literature
OtherTM9SF2 Reprograms Antigen Presenting Neutrophils to Overcome Immune Evasion in NSCLC
Immune evasion drives resistance to immunotherapy in non-small cell lung cancer (NSCLC), but the underlying mechanisms remain incompletely understood. Through a surfaceome-focused CRISPR screen, we identified Tm9sf2 as a critical regulator of immune evasion in NSCLC. We demonstrate that Tm9sf2 susta...
ORGANISM(S): Mus musculus 
2026-09-01 | GSE305250 | GEO
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