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MetabolomicsCeramide Disrupts TM9SF2-PGK1 Axis to Redirect PD-L1 Trafficking and Enhance Antitumor Immunity

The PD-1/PD-L1 axis represents a cornerstone of cancer immunotherapy, yet the dynamic shuttling of PD-L1 between endosomal recycling and lysosomal degradation routes limits durable responses. Using a CRISPR screen targeting glycosphingolipid metabolism, we identify TM9SF2 as a key regulator of PD...

2026-02-05 | MTBLS13838 | MetaboLights
ProteomicsSite mapping of PGK1 O-GlcNAcylation
To identify the site(s) of O-GlcNAcylation on PGK1, we transiently co-expressed Flag-tagged PGK1 and OGT in HEK293T cells. After immunoprecipitation using anti-Flag M2 beads and in-gel trypsin digestion, resulted peptides were subjected to mass spectrometry analysis
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD015659 | Pride
Pgk1 
ProteomicsIdentification of lactate-induced PGK1 K131 lactylation in hepatocellular carcinoma cells
Lactate accumulation is an important metabolic feature of hepatocellular carcinoma and may regulate tumor progression through lactate-dependent post-translational modifications. In this study, we investigated whether lactate-induced protein lactylation contributes to the regulation of phosphoglycera...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD080849 | Pride
Human  hepatocellular carcinoma  hcc  lactate  protein lactylation  lysine lactylation  pgk1  k131  immunoprecipitation  lc-ms/ms  tandem mass spectrometry  post-translational modification 
ProteomicsMapping the interactome of OSCC prognostic-associated proteins NDRG1 and PGK1 through proximity labeling using TurboID
Oral squamous cell carcinoma (OSCC) is a prevalent type of head and neck cancer, accounting for more than 90% of all oral malignancies worldwide. The identification of diagnostic and prognostic markers for OSCC is crucial for improving patient outcomes, as early detection and treatment are critical ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048046 | Pride
Ndrg1 Oral cancer Pgk1 Turboid Interactome Proximity labeling Prognostic 
ProteomicsIdentification of Aurora B phosphorylation mediated by KAT2A-treated PGK1 in vitro
The dataset was generated to characterize Aurora B phosphorylation following the KAT2A-PGK1 in vitro reaction.
ORGANISM(S): Homo sapiens (Human) 
2026-09-04 | PXD083647 | Pride
Human  hepatocellular carcinoma  hcc  lactate  protein lactylation  lysine lactylation  pgk1  k131  immunoprecipitation  lc-ms/ms  pgk1  aurora b  aurkb  kat2a  lactylation  phosphorylation 
ProteomicsMapping ISG15 sites on GAPDH and PGK1 by AP-MS
We employed an AP-MS approach to map ISG15 modification sites on GAPDH and PGK1 in HEK293T cells by overexpression of FLAG-GAPDH, FLAG-PGK1 or FLAG-GFP together with the ISG15 conjugation enzymes (E1, E2, E3) and wild-type HA-ISG15 or conjugation-defective ISG15-AA. Cells were lysed in physiological...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD071724 | Pride
Ap-ms Pgk1 Gapdh Isg15 Glycolysis 
GenomicsPGK1 acts as a non-catalytic gatekeeper of ferroptosis by stabilizing SLC7A11
PGK1 acts as a non-catalytic gatekeeper of ferroptosis by stabilizing SLC7A11
PRJNA1412666 | ENA
GenomicsPGK1 acts as a non-catalytic gatekeeper of ferroptosis by stabilizing SLC7A11 [scRNA-seq]
PGK1 acts as a non-catalytic gatekeeper of ferroptosis by stabilizing SLC7A11 [scRNA-seq]
PRJNA1415234 | ENA
TranscriptomicsPGK1 acts as a non-catalytic gatekeeper of ferroptosis by stabilizing SLC7A11
Ferroptosis is restrained by layered antioxidant defenses, yet whether glycolytic enzymes directly constitute ferroptosis-defense machinery remains unclear. Here we identify phosphoglycerate kinase 1 (PGK1) as a non-canonical suppressor of ferroptosis that functions independently of its glycolytic k...
ORGANISM(S): Homo sapiens 
2026-07-12 | GSE317428 | GEO
UnknownA Hemizygous Deletion Within the PGK1 Gene in Males with PGK1 Deficiency.
Not available
S-EPMC6336546 | biostudies-literature
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