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TranscriptomicsTranscription profiling by array of Rattus norvegicus cardiomyocytes to investigate the effects of PD184352 and BI-D1870 on changes in expression induced by endothelin-1
Cardiomyocytes were exposed to PD184352, BI-D1870 or endothelin-1 alone, or to endothelin-1 in the presence of each inhibitor
ORGANISM(S): Rattus norvegicus 
2013-01-16 | E-MEXP-3679 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat neonatal ventricular cardiac mycocytes exposed to endothelin-1 and C3 toxin
Effects of C3 toxin on RNA profiles in neonatal rat ventricular cardiac myocytes exposed to endothelin-1 (1 h)
ORGANISM(S): Rattus norvegicus 
2010-05-25 | E-MEXP-1977 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of rat heart ventricular myocytes treated either with PD184352 alone or PD184352 and endothelin-1.
Effects of PD184352 on RNA profiles in neonatal rat cardiomyocytes exposed to endothelin-1
ORGANISM(S): Rattus norvegicus 
2010-05-26 | E-MEXP-2516 | biostudies-arrayexpress
TranscriptomicsEffect of 60 min exposure to endothelin-1 on the cardiac myocyte transcriptome
Cardiac myocytes were unstimulated or exposed to 100 nM endothelin-1 for 60 min
ORGANISM(S): Rattus norvegicus 
2012-10-01 | E-MEXP-3394 | biostudies-arrayexpress
TranscriptomicsEffect of 30 or 90 min exposure to endothelin-1 on the cardiac myocyte transcriptome
Cardiac myocytes were exposed to 100 nM endothelin-1 for 30 or 90 min to determine effects on mRNA expression using Exon arrays
ORGANISM(S): Rattus norvegicus 
2012-10-01 | E-MEXP-3393 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary dermal fibroblasts treated with endothelin-1
Mouse primary dermal fibroblasts were treated with 100 nM endothelin-1 (ET1) synthetic peptide for 24 hours. Control samples received no ET1 peptide. The experiment compared treated to untreated to identify gene expression changes due to ET1 exposure. There are three biological replicates for bot...
ORGANISM(S): Mus musculus 
2005-01-01 | E-MEXP-700 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array to study the effect of adenoviruses encoding the FLAG epitope or full-length antisense sequence to Atf3 on transcriptional regulation in rat cardiac myocytes
Cardiomyocytes, the terminally-differentiated contractile cells of the heart, undergo hypertrophic growth in response to endothelin-1. This is associated with changes in mRNA expression of immediate early genes (IEGs). Atf3 is a member of the ATF/CREB family transcription factors which bind as dim...
ORGANISM(S): Rattus norvegicus 
2012-10-01 | E-MEXP-3392 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary lung fibroblasts to investigate the effect of a 4 hour treatment of 100 nM endothelin-1
primary lung fibroblasts p3 from normal periphery of resected cancer. grown in DMEM 10% FBS, until confluence, then DMEM 0.5% FBS for 18 hours. Media were then changed and incubated for an additional 4 hours in the presence or absence of 100 nM endothelin-1. Data represent two independent experimen...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1081 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse dermal fibroblasts following exposure to endothelin-1
To determine if aberrant activation of endothelin-1 (Et1) could lead to the dysregulation of many downstream genes, we exposed fibroblasts to exogenous ET1 peptide and assayed for transcriptional changes by microarray. Mouse dermal fibroblasts were treated with exogenous Et1 peptide for 24 hours. ...
ORGANISM(S): Mus musculus 
2007-06-29 | E-GEOD-4695 | biostudies-arrayexpress
TranscriptomicsRNAseq of iPSC derived cardiomyocytes in response to endothelin-1 as a model for cardiac hypertrophy
The study aims to develop an in vitro model of cardiac hypertrophy using human induced pluripotent stem cells (hPSCs). Human stem cell based disease models are important for reducing the number of animals used in research and to get data the is more relevant to humans. We stimulated hiPSCs derived c...
ORGANISM(S): Homo sapiens 
2020-09-01 | E-MTAB-8548 | biostudies-arrayexpress
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