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Alcohol-associated liver disease (ALD) is a growing global health concern, with alcohol-associated hepatitis (AH) leading to the highest morbidity and mortality. Available therapies are limited and often inadequate. Platelets contribute in a variety of ways to the pathogenesis of liver diseases, but...
ORGANISM(S): Homo sapiens (Human) 
2026-06-26 | PXD078511 | Pride
Platelet-derived S100A9 contributes to Endotheliopathy in Alcohol-Associated Hepatitis
Platelet-derived S100A9 contributes to Endotheliopathy in Alcohol-Associated Hepatitis [PBS and Aspirin]
COVID-19 is associated with endotheliopathy and coagulopathy, potentially leading to multi-organ failure. However, the direct mechanisms by which SARS-CoV-2 infection leads to endothelial damage are unclear. Here we developed an infection-competent human vascular organoid from pluripotent stem cells...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044386 | Pride
Alcohol-associated liver disease (ALD) is a growing global health concern, with alcohol-associated hepatitis (AH) leading to the highest morbidity and mortality. Available therapies are limited and often inadequate. Platelets contribute in a variety of ways to the pathogenesis of liver diseases, but...
ORGANISM(S): Homo sapiens 
2026-06-26 | GSE333389 | GEO
Alcohol-associated liver disease (ALD) is a growing global health concern, with alcohol-associated hepatitis (AH) leading to the highest morbidity and mortality. Available therapies are limited and often inadequate. Platelets contribute in a variety of ways to the pathogenesis of liver diseases, but...
ORGANISM(S): Mus musculus 
2026-06-26 | GSE333391 | GEO
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