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TranscriptomicsKinetic gene expression profiles of chicken macrophage HD11 cells in response to endotoxin from Salmonella typhimurium-798
HD11 cells were stimulated with 1 ug/ml endotoxin from ST-798 for 1, 2, 4 and 8 hours Cells were harvested at 1, 2, 4 and 8 hrs post stimulation and RNA was isolated from these cells and microarray was conducted for these RNA samples using affymetrix genechips The microarray experiment was conducted...
ORGANISM(S): Gallus gallus 
2010-10-19 | E-GEOD-23881 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood mononuclear cells, or whole blood were isolated 0, 30 min, 6 h, 24 h, and 7 day after intravenous endotoxin challenge vs controls
Peripheral blood mononuclear cells were isolated 0, 30 min, 6 h, 24 h, and 7 day after intravenous endotoxin challenge using cell preparation tubes (Vacutainer® CPT). The PBMC layer was lysed with RLT buffer, homogenized, and then stored at –80°C. Total RNA was extracted as per RNeasy‚ Midi protocol...
ORGANISM(S): Homo sapiens 
2007-12-19 | E-GEOD-3026 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neutrophils obtained after exposure endotoxin by bronchoscopic instillation reveals differential gene expression between air space and circulating neutrophils
Although the accumulation of neutrophils in the lungs and airways is common to many inflammatory lung diseases, including acute lung injury, the alterations that neutrophils undergo as they leave the peripheral circulation and migrate into the lungs have not been well characterized. Human volunteers...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-2322 | biostudies-arrayexpress
GenomicsMouse kidney endotoxin time course
Mouse kidney endotoxin time course
PRJNA1040219 | ENA
ProteomicsTMT-based quantitative proteomics of plasma from chicken challenged with lipopolysaccharide endotoxin
The change in the plasma proteome in chicken (Gallus gallus) challenged with lipopolysaccharide (endotoxin) derived from E. coli was determined by relative quantitation using a TMT label-based approach. This study provides insights into different factors contributing to innate immune response to exp...
ORGANISM(S): Gallus gallus (Chicken) 
2018-08-20 | PXD009399 | Pride
Tmt Lipopolysaccharide endotoxin infection Plasma Chicken Quantitative proteomics 
TranscriptomicsTranscriptome analysis of in vitro endotoxin tolerant human monocytes
Monocyte exposure to lipopolysaccharide (LPS) induces a transient state in which these cells are refractory to further endotoxin stimulation. Here we demonstrate the transcriptome analysis of in vitro generated LPS refractory monocytes upon subsequent re-exposure to LPS for different time points. To...
ORGANISM(S): Homo sapiens 
2009-03-13 | E-GEOD-15219 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of spleens from dual specificity phosphatase-1 (DUSP1) deficient and wild type mice to demonstrate a specific regulatory role of DUSP1 on a subset of LPS-induced genes that control the outcome of endotoxin shock.
Activation of the Mitogen activated protein kinase (MAPK) cascade following Toll-like receptor (TLR) stimulation enables innate immune cells to rapidly activate cytokine gene expression. A balanced response to signals of infectious danger requires that cellular activation is transient. Here, we iden...
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-3565 | biostudies-arrayexpress
GenomicsEndotoxin stimulates lipolysis in bovine adipocytes
Endotoxin stimulates lipolysis in bovine adipocytes
PRJNA1109839 | ENA
TranscriptomicsGene Expression in the Liver after endotoxin
Acute Respiratory Distress Syndrome (ARDS) is a very common clinical entity and a major cause of morbidity and mortality in the critical care setting. Historically, ARDS has been associated with mortality ranging from 40% to 60% . In the US alone,200,000 new cases of ARDS occur every year. ARDS can ...
ORGANISM(S): Sus scrofa 
2013-01-10 | E-MTAB-1436 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression analysis during endotoxin tolerance in PBMCs.
Genome-wide gene expression was measured in peripheral blood mononuclear cells (PBMC) from healthy humans donors, four hours post stimulation of a single or double treatment of LPS and compared to untreated control PBMCs. We show that a second treatment with LPS induces endotoxin tolerance, with a ...
ORGANISM(S): Homo sapiens 
2011-05-17 | E-GEOD-22248 | biostudies-arrayexpress
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