Sort   by:  
 Page size 
UnknownNovel 9q34.11 gene deletions encompassing combinations of four Mendelian disease genes: STXBP1, SPTAN1, ENG, and TOR1A.
Not available
S-EPMC3713627 | biostudies-literature
TranscriptomicsEvaluation of effect of PTEN gene deletion in mouse CD4+ Th1 clones after stimulation
PTEN is thought to play a critical role in T cell activation by negatively regulating the PI3K signaling pathway important for cellular activation, growth, and proliferation. T cells from mice in which PTEN was conditionally deleted in the thymus were reported to display CD28-independent IL-2 produ...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-43936 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA seq of influenza tetramer specific CD8+ T cells from baseline, acute and long term memory timepoints
The aim of the experiment was to assess the differentiation and activation status of influenza-specific CD8+ T cells (A2/PB1 413 and A2/BHA 543) from an individual naturally infected with influenza B (PCR-confirmed). Single tetramer+ CD8+ T cells from tetramer-enriched PBMCs were sorted from baselin...
ORGANISM(S): Homo sapiens 
2019-02-18 | E-MTAB-7606 | biostudies-arrayexpress
TranscriptomicsThe expanded regulatory T cell population in chronic filarial infection is highly heterogeneous, activated and suppresses dendritic cell function indirectly through effector T cells.
Natural regulatory T cells (nTregs) are known to increase during chronic infection or at the site tumor, though the exact mechanisms that contribute to their accumulation and mode of action remain unclear. We used flow cytometry and microarray analyses to delineate the phenotype of nTregs and their ...
ORGANISM(S): Homo sapiens 
2016-02-25 | E-GEOD-44767 | biostudies-arrayexpress
TranscriptomicsGeneration of NPM1-ALK translocation in human T lymphocytes faithfully recapitulates the diversity of ALK+ ALCL tumor phenotype
To recapitulate the t(2;5)(p23;q35) chromosomal translocation, activated T lymphocytes from healthy donors PBMC were transfected with the RNP complex composed of the protein Cas9 with gRNA NPM1 (targeting NPM1 gene) and gRNA ALK (targeting ALK gene). Control cells were wild-type CD4+ activated lymp...
ORGANISM(S): Homo sapiens 
2022-02-09 | E-MTAB-10924 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of human CD8+ T cells binding the IAV HLA-A24/PB1 498-505 tetramer
PBMCs from 4 donors were stained with the influenza A virus HLA-A24/PB1 498-505 tetramer. Two donors (non-LIFT8 and non-LIFT12) showed TCR independent KIR binding to tetramers whereas the other two donors (Non-LIFT14 and Non-LIFT10) showed TCR specific binding. Cells were single-cell sorted on a BD ...
ORGANISM(S): Homo sapiens 
2021-04-08 | E-MTAB-10109 | biostudies-arrayexpress
TranscriptomicsExpression profile of third instar larval fat body and midgut tissues
We use mRNA-seq to transcriptionally profile larval fat body and midgut tissues from Drosophila third instar larvae. These data provide insights into tissue physiology and can be used to identify tissue specific transcripts. Fat bodies from wandering third instar larvae were dissected from ~50 male ...
ORGANISM(S): Drosophila melanogaster 
2010-11-02 | E-GEOD-25025 | biostudies-arrayexpress
UnknownSystematic Analysis of the Transcriptome Profiles and Co-Expression Networks of Tumour Endothelial Cells Identifies Several Tumour-Associated Modules and Potential Therapeutic Targets in Hepatocellular Carcinoma.
Not available
S-EPMC8067977 | biostudies-literature
UnknownPathogenic Variant Frequencies in Hereditary Haemorrhagic Telangiectasia Support Clinical Evidence of Protection from Myocardial Infarction.
Not available
S-EPMC10779873 | biostudies-literature
UnknownIdentification and validation of a novel pathogenic variant in GDF2 (BMP9) responsible for hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations.
Not available
S-EPMC9939255 | biostudies-literature
Sort   by:  
 Page size