Engineered vesicles

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Organisms

Mus musculus (22)
Homo sapiens (17)
Rattus norvegicus (3)
Cervus nippon (1)
Salmonella enterica subsp. enterica serovar Typhimurium (1)
Salmonella enterica subsp. enterica (1)
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Repository

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Tissue

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Disease free (2)
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Technology Type

Mass Spectrometry (19)
Shotgun proteomics (10)
Bottom-up proteomics (4)
Data-dependent acquisition (3)
Data-independent acquisition (3)
Mass spectrometry assay (2)
Top-down proteomics (2)
Mass spectrometry (1)

Instrument Platform

6545 Q-TOF LC/MS (4)
Liquid Chromatography MS - alternating - hilic (2)
LTQ Orbitrap Elite (1)
Q Exactive (1)
Liquid Chromatography MS - positive - reverse-phase (1)
Liquid Chromatography MS - negative - reverse-phase (1)

Metabolite Name

1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-.alpha.,.alpha.- dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid (2)
Sulfamonomethoxine (2)
2-Acetamido-3-(4-hydroxy-3-methoxyphenyl)propanoic acid (2)
Mepacrine (2)
Tetrahydroharman-3-carboxylic acid (2)
Ivacaftor (2)
Ranolazine (2)
Thr-Pro (2)
Lys-Ile (2)
Tetracycline (2)
7-Methylguanine (2)
Purine (2)
Pantothenic acid (2)
Xanthosine (2)
Val-Met (2)
Thr-Ala (2)
Phenylalanine (2)
Val-Ile (2)
Sucrose (2)
Levofloxacin (2)
Hypoxanthine (2)
0 (1)
{[(4-Hydroxyphenyl)acetyl]amino}acetic acid (1)
Trans-4-(Aminomethyl)cyclohexanecarboxylic acid (1)
Tert-Butyl 4-(2-aminoethyl)-1-piperazinecarboxylate (1)
O-Tolidine (1)
All-trans-Retinoic acid methyl ester (1)
[6,10a-Dihydroxy-4-(hydroxymethyl)-4,7,11b-trimethyl-9-oxo-1,2,3,4a,5,6,6a,7,11,11a-decahydronaphtho[2,1-f][1]benzofuran-5-yl] acetate (1)
[3-Nitro-4-(1-piperidinyl)phenyl](phenyl)methanone (1)
[2-(6,7-Dimethoxyquinazolin-4-yl)-5-(2-pyridyl)-1,2,4-triazol-3-yl]amine (1)

First Public Date

2026 (27)
2025 (18)
2023 (6)
2024 (3)
2022 (3)
2019 (3)
2021 (2)
2018 (1)
2017 (1)

Classification

bacteria (2)

Release Date

2025 (171)
2024 (108)
2022 (97)
2023 (94)
2021 (74)
2020 (44)
2026 (30)
2018 (27)
2019 (26)
2017 (22)
2016 (20)
2015 (9)
2014 (9)
2010 (4)
2013 (3)
2012 (3)
2011 (3)
2009 (3)
2008 (1)
2007 (1)
2006 (1)
2002 (1)
2001 (1)

Lab affiliation

1Gavin Herbert Eye Institute –Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California Irvine, Irvine, CA 92697, USA 2Department of Physiology and Biophysics, University of California Irvine, Irvine, CA 92697, USA 3Department of Chemistry, University of California Irvine, Irvine, CA 92697, USA 4Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA (1)
Baker Institute (1)
CRUK - Beatson Institute for Cancer Research - Switchback Rd, Bearsden, Glasgow G61 1BD - United Kingdom (1)
Cellular Proteomics Group Helmholtz Centre for Infection Research Inhoffenstr. 7 38124 Braunschweig Germany (1)
Cornell University (1)
DZNE Munich, Neuroproteomics, Feodor-Lynen-Str. 17, 81377 München, Germany (1)
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA (1)
Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, South Korea (1)
Department of Hematology, Erasmus MC, Rotterdam, the Netherlands (1)
Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA (1)
Department of Molecular Pharmacology, Einstein Institute of Neuroimmunology and Inflammation, Albert Einstein College of Medicine, Bronx, NY 10461, USA (1)
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China. (1)
Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium (1)
Mass Spectrometry Technology Access Center, McDonnell Genome Institute, Washington University School of Medicine (1)
Proteomics Core Facility, Sahlgrenska Akademy, University of Gothenburg, Sweden (1)
Proteomics Core facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (1)
Ruth and Tristram Colket Jr. Translational Research Building Room 3050 3501 Civic Center Blvd Philadelphia, PA 19104 (1)
SHIFTBIO INC., Seoul, Republic of Korea, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Republic of Korea (1)
University of Chieti-Pescara, Depatment of Pharmacy (1)

Publication date

2026 (28)
2025 (21)
2022 (6)
2023 (6)
2021 (4)
2024 (3)
2019 (3)
2020 (2)
2018 (1)
2017 (1)

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Proteomic and metabolomic profiling of extracellular vesicles produced by human gut archaea

Gastrointestinal bacteria interact with the host and each other through various mechanisms, including the production of extracellular vesicles (EVs). However, the composition and potential roles of EVs released by gut archaea are poorly understood. Here, we study EVs produced by four strains of h...

2025-07-01 | MTBLS12422 | MetaboLights

Metabolic-engineered probiotic-OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapy

Chronic, drug-resistant bone infection caused by methicillin-resistant Staphylococcus aureus (MRSA) features an immunosuppressive niche enabling persistent infection and impaired bone healing. Specific treatment requires initial antibacterial immune activation against infection, followed by resha...

2026-03-19 | MTBLS14091 | MetaboLights

Prevention of acute graft-versus-host disease via single-dose administration of bioengineered extracellular vesicles

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for various hematological and immunologic diseases, but acute graft-versus-host disease (aGVHD) remains a major cause of morbidity and mortality. We previously discovered in patients and murine models that higher le...

2026-09-11 | MTBLS15633 | MetaboLights

Nanobody engineered and photosensitiser loaded bacterial outer membrane vesicles potentiate anti-tumor immunity and immunotherapy

PRJNA1136034 | ENA

Differential microRNA profiles of intramuscular and secreted extracellular vesicles in human tissue-engineered muscle

PRJNA838871 | ENA

Engineered Extracellular Vesicles Prepared by Membrane Extrusion Are Good Substitutes for Natural Extracellular Vesicles

Extracellular vesicles (EV) as drug delivery nanocarriers are under intense investigation. Although clinical-grade EVs have been produced on a large-scale, low yield and high production costs of natural EVs (nEV) limit the relevant industrial translation. Recent studies show that mechanical extrusio...

ORGANISM(S): Homo sapiens (Human)

2023-03-11 | PXD030826 | Pride

HaloTag display enables quantitative single-particle characterisation and functionalisation of engineered extracellular vesicles.

Not available

S-EPMC11224594 | biostudies-literature

Engineered MSC-derived extracellular vesicles maintain proteomic characteristics comparable with naïve MSC-derived extracellular vesicles

Extracellular vesicles reflect the contents and characteristics of their donor cells. When donor cells were engineered to express specific protein, their characteristic may change, potentially altering the composition of EVs. This study aims to evaluate the degree of similarity in protein contents b...

ORGANISM(S): Homo sapiens (Human)

2025-01-31 | PXD060047 | Pride

Human Lc-msms Extracellular vesicle Mesenchymal stem cell Engineered extracellular vesicle

Engineered Cas9 extracellular vesicles as a novel gene editing tool.

Not available

S-EPMC9117459 | biostudies-literature

Quantification of protein cargo loading into engineered extracellular vesicles at single-vesicle and single-molecule resolution.

Not available

S-EPMC8329990 | biostudies-literature

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