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The diversity and complexity of the microbiome's genomic landscape are not always mirrored in its proteomic profile. Despite the anticipated proteomic diversity, observed complexities of microbiome sample are often lower than expected. Two main factors contribute to this discrepancy: limitations in ...
ORGANISM(S): gut metagenome 
2024-05-27 | PXD050781 | Pride
Proteases are crucial physiologic regulators of protein structure and function. While proteomic methods contributed extensively to protease characterization efforts, technical challenges remain in terms of throughput, scalability and large datasets of protease cleavages remain scarce. Here, we descr...
ORGANISM(S): Homo sapiens (Human) 
2021-02-05 | PXD018976 | Pride
DNA methylation entropy is a biomarker for aging
The dynamic nature of epigenetic modifications has been leveraged to construct epigenetic clocks that accurately predict an individual’s age based on DNA methylation levels. Here we explore whether the accumulation of epimutations, which can be quantified by Shannon’s entropy, changes reproducibly w...
ORGANISM(S): Homo sapiens 
2025-01-27 | GSE288139 | GEO
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