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MetabolomicsPaternal microbiome perturbations impact offspring fitness

The gut microbiota operates at the interface of host-environment interactions to influence human homeostasis and metabolic networks. Environmental factors that unbalance gut microbial ecosystems can therefore elicit physiological and disease-associated responses across somatic tissues. However, t...

2024-02-12 | MTBLS1629 | MetaboLights
MetabolomicsGain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. Because of substantial functional overlap, the interplay and relative contributions of SL...

2022-09-20 | MTBLS4268 | MetaboLights
TranscriptomicsComparison of salt stress resistance genes in transgenic Arabidopsis thaliana indicates that extent of transcriptomic change may not predict secondary phenotypic or fitness effects
Engineered abiotic stress resistance is an important target for increasing agricultural productivity.There are concerns, however, regarding possible ecological impacts of transgenic crops. In contrast to the first wave of transgenic crops, many abiotic stress resistance genes can initiate complex do...
ORGANISM(S): Arabidopsis thaliana 
2011-10-05 | E-GEOD-26983 | biostudies-arrayexpress
GenomicsThe genetic architecture of hybrid fitness under environmental stress
The genetic architecture of hybrid fitness under environmental stress
PRJEB33368 | ENA
TranscriptomicsTranscriptomics of environmental adaptation and survival in wild adult Pacific Sockeye Salmon (Oncorhynchus nerka) during spawning migration
a salmonid microarray was used to characterize environmentally-regulated shifts in gene expression between ocean and river habitats in gill and liver tissues of wild migrating adult Pacific sockeye salmon (Oncorhynchus nerka). To correlate gene expression with survival, non-lethal biopsy sampling of...
ORGANISM(S): Oncorhynchus nerka 
2011-06-12 | E-GEOD-22346 | biostudies-arrayexpress
TranscriptomicsMassively parallel interrogation of the effects of gene expression levels on cellular fitness
Data of gene expression levels across individuals, cell types, and disease states is rapidly expanding, yet we have limited understanding of how expression levels impact cellular and organismal phenotypes. Here, we present a massively parallel system for assaying the effect of gene expression levels...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-25 | E-GEOD-83936 | biostudies-arrayexpress
ProteomicsSuppressed Protein Translation Caused by MSP-8 Defect Determines Fungal Multidrug Resistance with Fitness Cost
Antifungal resistance, particularly the rise in multidrug resistance, has become a critical public health concern, garnering substantial attention. In this study, we used experimental evolution with Neurospora crassa as a model and identified a novel multidrug-resistance gene, msp-8, which encodes a...
ORGANISM(S): Neurospora Crassa Or74a 
2024-08-02 | PXD054574 |
ProteomicsIn vivo fitness of sul gene-dependent sulfonamide-resistant Escherichia coli in the mammalian gut
Sulfonamides are traditional synthetic antimicrobial agents used in clinical and veterinary medical settings. Their long-term excessive overuse has resulted in widespread microbial resistance, limiting their application for medical interventions. Resistance to sulfonamides is primarily conferred by ...
ORGANISM(S): Escherichia Coli Str. K-12 Substr. Mg1655 
2024-07-04 | PXD053633 |
TranscriptomicsIdentification of differentially expressed genes between clinical and bovine-biased Escherichia coli O157:H7 genotypes
Escherichia coli O157:H7 strains have been classified into different genotypes based on the presence of specific shiga toxin-encoding bacteriophage insertion sites. Genotypes that are predominant in clinical isolates are named clinical genotypes and those that are isolated mostly from bovine source...
ORGANISM(S): Escherichia coli 
2010-06-19 | E-GEOD-15783 | biostudies-arrayexpress
TranscriptomicsArgR is an essential local transcriptional regulator of the arcABC-operon in Streptococcus suis and crucial for biological fitness in acidic environment
Transcriptome comparison of Streptococcus suis wildtype and argR knock-out strain grown to exponential or early-stationary phase, respectively.
ORGANISM(S): Streptococcus suis 
2010-10-17 | E-MEXP-2945 | biostudies-arrayexpress
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