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MetabolomicsResponse Mechanisms of Hepatopancreatic Metabolism and Gut Microbiota in Chinese Mitten Crab (Eriocheir sinensis) Under Chronic High-pH Stress

This study subjected Eriocheir sinensis to chronic high-pH stress (control: pH=8; experimental groups: pH=9 and pH=10) and integrated hepatopancreas transcriptomic/metabolomic analyses with intestinal microbiota 16S rRNA sequencing to explore its adaptive mechanisms. The results revealed distinct...

2026-07-04 | MTBLS13708 | MetaboLights
MetabolomicsThe metabolic response of marine copepods to environmental warming and ocean acidification in the absence of food
Marine copepods are central to the productivity and biogeochemistry of marine ecosystems. Nevertheless, the direct and indirect effects of climate change on their metabolic functioning remain poorly understood. Here, we use metabolomics, the unbiased study of multiple low molecular weight organic me...
2015-10-13 | MTBLS91 | MetaboLights
MetabolomicsMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal t...
2021-09-27 | MTBLS1531 | MetaboLights
MetabolomicsEnvironmental Chemical Diethylhexyl Phthalate Alters Intestinal Microbiota Community Structure and Metabolite Profile in Mice
Exposure to environmental chemicals during windows of development is a potentially contributing factor in gut microbiota dysbiosis, and linked to chronic diseases and developmental disorders. We used a community-level model of microbiota metabolism to investigate the effects of diethylhexyl phthalat...
2022-01-17 | MTBLS861 | MetaboLights
TranscriptomicsEffect of pH on Cadmium Toxicity in Escherichia coli
Metals at high concentrations can exert toxic effects on microorganisms. It has been widely reported that lowering environmental pH reduces effects of cadmium toxicity in bacteria. Understanding the effects of pH-mediated cadmium toxicity on bacteria would be useful for minimizing cadmium toxicity...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2008-08-21 | E-GEOD-12373 | biostudies-arrayexpress
TranscriptomicsLactobacillus plantarum IMDO 130201, a wheat sourdough isolate, adapts to growth in wheat sourdough simulation medium at different pH values through differential gene expression
Sourdough is a very competitive and challenging environment for microorganisms. Usually, a stable microbiota composed of lactic acid bacteria (LAB) and yeasts comes to dominate this ecosystem. Although rich in carbohydrates, thus providing an ideal environment to grow, the low pH presents a particul...
ORGANISM(S): Lactobacillus plantarum 
2011-07-31 | E-GEOD-23945 | biostudies-arrayexpress
ProteomicsProtein Phosphorylation Orchestrates Acclimations of Arabidopsis Plants to Environmental pH
In lieu of strategies to escape unfavorable conditions, plants have evolved mechanisms to cope with and adapt to changes in their environment. Environment pH (pHe) is a key parameter that dictates a surfeit of conditions of critical importance for plant survival and fitness. Besides responses to alt...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-09-18 | PXD045226 | Pride
Arabidopsis Protein phosphorylation Environment ph 
TranscriptomicsIdentification of HP0244 regulon at different pH conditions
Transcriptional profiling of Helicobacter pylori comparing 26695 wild-type strain and a HP0244-deficient mutant 26695/∆HP0244::km treated at three different pH conditions (pH 7.4, pH 4.5 without urea, or pH 2.5 with 30 mM urea) for 30 min to define the HP0244 acid-responsive regulon Keywords: Gen...
ORGANISM(S): Helicobacter pylori 
2010-05-05 | E-GEOD-12900 | biostudies-arrayexpress
TranscriptomicsMycobacterium tuberculosis transcriptional responses to acidic pH and carbon source
The purpose of this study was to examine how Mtb integrates acidic pH and available carbon sources as environmental cues to regulate its metabolism and growth rate. RNA-seq transcriptional profiling of M. tuberculosis growing at acidic or neutral pH, in pyruvate or glycerol, was examined. These stu...
ORGANISM(S): Mycobacterium tuberculosis 
2014-07-07 | E-GEOD-52020 | biostudies-arrayexpress
TranscriptomicsThe pH-sensing receptor OGR1 improves barrier function of CaCo-2 cells and inhibits migration in an acidic environment
OGR1 is a pH-sensing G-protein coupled receptor involved in intestinal homeostasis and inflammation Proton activation of OGR1 increases barrier function in Caco2 cells Microarray profiling was performed on OGR1 stable overexpressing Caco-2 cells during acidic pH shift
ORGANISM(S): Homo sapiens 
2015-08-13 | E-GEOD-60294 | biostudies-arrayexpress
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