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MetabolomicsThe genomic and enzymatic basis for iridoid biosynthesis in cat thyme (Teucrium marum)
Iridoids are non-canonical monoterpenoids produced by both insects and plants. An example is the cat attracting and insect repelling volatile iridoid nepetalactone, produced by Nepeta sp. (catmint) and aphids. Recently, both nepetalactone biosynthetic pathways were elucidated, showing a remarkable c...
2026-04-20 | MTBLS9357 | MetaboLights
MetabolomicsInterorganelle lipid flux revealed by enzymatic mass tagging in vivo
The distinct activities of cellular organelles are dependent on the proper function of their membranes. Coordinated membrane biogenesis of the different organelles necessitates interorganelle transport of lipids from their site of synthesis to their destination membranes. Several proteins and traffi...
2022-03-22 | MTBLS3415 | MetaboLights
MetabolomicsMicrobial -Enzymatic Mucin Metabolic Relay Suppresses Tumor Progression in Apcmin/+ mice

Compelling evidence established the gut microbiota as a pivotal regulator of colorectal cancer (CRC) progression, although stage-specific mechanisms remain unclear. Our investigation in Apcmin/+ mice mapped tumor growth and microbial shifts across early, intermediate, and advanced stage...

2025-07-20 | MTBLS12754 | MetaboLights
MetabolomicsMicrobial -Enzymatic Mucin Metabolic Relay Suppresses Tumor Progression in Apcmin/+ mice

Compelling evidence established the gut microbiota as a pivotal regulator of colorectal cancer (CRC) progression, although stage-specific mechanisms remain unclear. Our investigation in Apcmin/+ mice mapped tumor growth and microbial shifts across early, intermediate, and advanced stage...

2025-07-24 | MTBLS12770 | MetaboLights
MetabolomicsIonomic, Metabolomic, and Enzymatic Responses of the Sea Cucumber Apostichopus japonicus to Single and Combined Salinity and Metal Stress

Desalination brine discharge poses emerging threats to benthic marine organisms through combined salinity stress and metal contamination. This study investigated the individual and combined effects of salinity (35 ppt) and metal exposure (Cu, Fe, and Cd) on the sea cucumber Apostichopus japonicus...

2026-03-18 | MTBLS14079 | MetaboLights
ProteomicsAre there enzymatic treatment options for ocular biofilm-based infections?
Pseudomonas aeruginosa-induced corneal keratitis is a sight-threatening disease. The elevated rise of antibiotic resistance among the Pseudomonas keratitis isolates makes treatment of this disease challenging, justifying the need for alternative therapeutic modalities or treatment strategies that ca...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-15 | PXD009767 | Pride
Keratitis P. aeruginosa Neutrophils Enzymatic treatment Biofilms 
GenomicsEnzymatic treatment using trypsin and cold-active protease for C2C12 myoblasts
Enzymatic treatment using trypsin and cold-active protease for C2C12 myoblasts
PRJNA707443 | ENA
GenomicsLow pass whole methylome enzymatic sequencing of four AML cell lines untreated and after treatment with different concentrations of 5-azacytidine (AZA), 5-aza-2′-deoxycytidine (DEC), Cytarabine (ARAC) and GSK3685032 (GSK5032) for 3 and 7 days
We conducted low-coverage whole-genome enzymatic methylation sequencing (EM-seq) on four commercially available AML cell lines to assess their global DNA methylation profiles following treatment with varying concentrations (0–3000 nM) of three different hypomethylating agents—5-azacytidine (AZA), 5-...
ORGANISM(S): Homo sapiens 
2025-04-10 | E-MTAB-14969 | biostudies-arrayexpress
TranscriptomicsEnzymatic treatment using trypsin and cold-active protease for C2C12 myoblasts
We have comprehensively profiled the time-series changes in gene expression dependent on enzymatic treatment using trypsin, and attempted to elucidate the global changes suppressed by treatment with cold active protease in a low-temperature environment.
ORGANISM(S): Mus musculus 
2022-06-20 | GSE168452 | GEO
GenomicsLow pass whole methylome enzymatic sequencing of 11 T-ALL cell lines untreated and after treatment with different concentrations of 5-azacytidine (AZA), 5-aza-2′-deoxycytidine (DEC) and GSK3685032 (GSK5032) for 3 and 7 days
Here we performed low coverage whole genome enzymatic-mehtyl-conversion sequencing (EM-seq) of 11 commercially available T-ALL cell lines to evaluate their global DNA methylation profile. We then proceeded to treat ALL-SIL, SUP-T1, LOUCY and JURKAT with varying concentrations (0-3000 nM) of three di...
ORGANISM(S): Homo sapiens 
2024-10-13 | E-MTAB-14197 | biostudies-arrayexpress
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