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TranscriptomicsHuman Corneal microRNA Expression Profile in Fungal Keratitis
MicroRNAs (miRNAs) are small, stable non-coding RNA molecules with regulatory function and marked tissue specificity that post-transcriptionally regulate gene expression, however their role in fungal keratitis remain unknown. Our purpose was to identify the miRNAs in human cornea from fungal keratit...
ORGANISM(S): Homo sapiens 
2016-07-28 | E-GEOD-64843 | biostudies-arrayexpress
TranscriptomicsTranscriptome data for bacterial and fungal keratitis compared to cadaver cornea
Microbial keratitis is a major cause of blindness worldwide. An excessive host inflammatory response can occur even after adequate antimicrobial treatment. This results in tissue damage with corneal thinning and even perforation, which may require corneal transplantation. In this study we investigat...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-58291 | biostudies-arrayexpress
GenomicsNanopore Sequencing for Microbial Keratitis
Rapid Diagnosis of Microbial Keratitis using Nanopore Sequencing: a proof-of-concept study
PRJEB33660 | ENA
GenomicsHuman Corneal microRNA Expression Profile in Fungal Keratitis
MicroRNAs (miRNAs) are small, stable non-coding RNA molecules with regulatory function and marked tissue specificity that post-transcriptionally regulate gene expression, however their role in fungal keratitis remain unknown. Our purpose was to identify the miRNAs in human cornea from fungal keratit...
ORGANISM(S): Homo sapiens 
2016-07-28 | GSE64843 | GEO
ProteomicsAspergillus flavus Induced Alterations in Tear Protein Profile Reveal Pathogen-Induced Host Response to Fungal Infection
Aspergillus flavus and Fusarium sp. are primary causative agents of keratitis that results in corneal tissue damage leading to vision loss. The tear proteome of control and keratitis patients was profiled and compared. A total of 1873 proteins from control and 1400 proteins from patient tear were id...
ORGANISM(S): Homo sapiens (Human) 
2016-12-13 | PXD003825 | Pride
Mycotic keratitis  tear proteomics  complement  netosis  wound healing  glycosylation 
GenomicsTranscriptional profiling specifies the pathogen-specific human host response to infectious keratitis
Transcriptional profiling specifies the pathogen-specific human host response to infectious keratitis
PRJNA1009389 | ENA
TranscriptomicsTranscriptional profiling specifies the pathogen-specific human host response to infectious keratitis
PURPOSE Corneal infections are a leading cause of visual impairment and blindness worldwide. Here we applied high-resolution transcriptomic profiling to assess the general and pathogen-specific molecular and cellular mechanisms during human corneal infection. METHODS Clinical diagnoses of herpes sim...
ORGANISM(S): Homo sapiens 
2024-01-30 | GSE241715 | GEO
TranscriptomicsTranscriptome data for bacterial and fungal keratitis compared to cadaver cornea
Microbial keratitis is a major cause of blindness worldwide. An excessive host inflammatory response can occur even after adequate antimicrobial treatment. This results in tissue damage with corneal thinning and even perforation, which may require corneal transplantation. In this study we investigat...
ORGANISM(S): Homo sapiens 
2014-10-31 | GSE58291 | GEO
ProteomicsAre there enzymatic treatment options for ocular biofilm-based infections?
Pseudomonas aeruginosa-induced corneal keratitis is a sight-threatening disease. The elevated rise of antibiotic resistance among the Pseudomonas keratitis isolates makes treatment of this disease challenging, justifying the need for alternative therapeutic modalities or treatment strategies that ca...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-15 | PXD009767 | Pride
Keratitis P. aeruginosa Neutrophils Enzymatic treatment Biofilms 
Genomics
Keratitis sequencing
PRJNA877280 | ENA
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