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TranscriptomicsIdentification of immediate early transcriptional targets of ephrin-B1 forward signaling
The goal of this study was to identify immediate early transcriptional targets of ephrin-B1 forward signaling that are relevant to palatogenesis. The Ephs compose a family of receptor tyrosine kinase signaling molecules that can be activated by their cognate ligands, the ephrins. Despite the import...
ORGANISM(S): Mus musculus 
2010-09-20 | E-GEOD-23539 | biostudies-arrayexpress
MetabolomicsSphingosine-1-phosphate receptor 1 promotes ovarian cancer tumorsphere proliferation and metastasis
Despite extensive clinical endeavors to enhance high-grade serous ovarian cancer (HGSOC) detection and treatment, an alarming half of diagnosed women succumb annually to this disease. Significantly, nearly all HGSOC cases manifest ascites at diagnosis, a poor prognostic indicator. Malignant ascites ...
2026-03-04 | MTBLS13770 | MetaboLights
MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
ProteomicsTyrosine phosphoproteomics of patient-derived xenografts reveals ephrin type-B receptor 4 tyrosine kinase as novel therapeutic target in pancreatic cancer
Pancreatic ductal adenocarcinoma is a recalcitrant tumor with minimal response to conventional chemotherapeutic approaches. Oncogenic signaling by activated tyrosine kinases has been implicated in cancers resulting in activation of diverse effector signaling pathways. Thus, discovery of aberrantly a...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-05-24 | PXD021729 | Pride
Receptor tyrosine kinase Ptyr Pdx Signaling Cancer 
UnknownExpression and functional analyses of ephrin type-A receptor 2 in mouse spermatogonial stem cells†.
Not available
S-EPMC7305687 | biostudies-literature
UnknownIdentification and Therapeutic Intervention of Coactivated Anaplastic Lymphoma Kinase, Fibroblast Growth Factor Receptor 2, and Ephrin Type-A Receptor 5 Kinases in Hepatocellular Carcinoma.
Not available
S-EPMC6586030 | biostudies-literature
UnknownCrystallization and preliminary X-ray diffraction analysis of the complex of a human anti-ephrin type-A receptor 2 antibody fragment and its cognate antigen.
Not available
S-EPMC2882782 | biostudies-literature
TranscriptomicsMolecular markers associated with outcome and metastasis in human pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous cancer in which differences in survival rates might be related to a variety in gene expression profiles. Although the molecular biology of PDAC begins to be revealed, genes or pathways that specifically drive tumour progression or metastasis...
ORGANISM(S): Homo sapiens 
2013-01-09 | E-GEOD-42952 | biostudies-arrayexpress
ProteomicsHypothalamic Proteomics analysis of lipopolysaccharide (LPS)-induced depressed mice
Hypothalamic dysfunction is a key pathological factor in inflammation-associated depression. In the present study, isobaric tags for relative-absolute quantitation (iTRAQ) combined with mass spectrometry were employed to detect the proteomes in the hypothalamus of the lipopolysaccharide (LPS)-induce...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-09 | PXD016040 | Pride
Depression Hypothalamus Lipopolysaccharide Itraq lc-ms/ms Brain tissue 
ProteomicsProteome changes associated with effect of high-dose single-fractionation radiation on lung adenocarcinoma cell lines
Lung cancer is a leading cause of cancer-related mortality globally, with non-small cell lung cancer (NSCLC) representing 85% of cases. Advances in treatment modalities, including the emergence of antibody-drug conjugates and stereotactic radiation therapy, have improved outcomes. However, the possi...
ORGANISM(S): Homo sapiens (Human) 
2025-07-06 | PXD057576 | Pride
Proteomics Ephrin type-a receptor 2 High-dose radiation Lung adenocarcinoma 3d cell culture 
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