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ProteomicsPhosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
The intricate protein-chaperone network is vital for cellular function. Recent discoveries have unveiled the existence of specialized chaperone complexes called epichaperomes, protein assemblies orchestrating the reconfiguration of protein-protein interaction networks, enhancing cellular adaptabilit...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-10-17 | PXD050251 | Pride
Hsp90 Posttranslational modifications Epichaperome 
UnknownExperimental traumatic brain injury increases epichaperome formation.
Not available
S-EPMC10698712 | biostudies-literature
UnknownParadigms for Precision Medicine in Epichaperome Cancer Therapy.
Not available
S-EPMC6996250 | biostudies-literature
UnknownFirst-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer.
Not available
S-EPMC7541604 | biostudies-literature
UnknownPhosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation.
Not available
S-EPMC11484706 | biostudies-literature
UnknownTargeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia.
Not available
S-EPMC8155064 | biostudies-literature
UnknownChemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system.
Not available
S-EPMC8333062 | biostudies-literature
GenomicsTargeting the Epichaperome As an Effective Precision Medicine Approach in a Novel PML-SYK Fusion Acute Myeloid Leukemia
The epichaperome is a new cancer target composed of hyperconnected networks of chaperome members that facilitate cell survival. Cancers with an altered chaperone configuration may be susceptible to epichaperome inhibitors. We developed a flow cytometry-based assay for evaluation and monitoring of ep...
EGAS00001004992 | EGA
UnknownUnraveling the Mechanism of Epichaperome Modulation by Zelavespib: Biochemical Insights on Target Occupancy and Extended Residence Time at the Site of Action.
Not available
S-EPMC10604720 | biostudies-literature
UnknownThe epichaperome is an integrated chaperome network that facilitates tumour survival.
Not available
S-EPMC5283383 | biostudies-literature
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