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MetabolomicsFatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols
Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4-/- mice die neonatally from a defective barrier. H...
2021-07-15 | MTBLS1138 | MetaboLights
TranscriptomicsExpression data from normal human epidermal keratinocytes undergoing density-induced differentiation and treated with EGF
Combining genome-wide microarray and functional analyses, we found that EGFR activation abrogates barrier function, increasing transepidermal water loss (TEWL) and transepithelial permeability of water-soluble ions and higher molecular weight dextrans, in part by disrupting the expression of tight j...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-32217 | biostudies-arrayexpress
TranscriptomicsKey roles for SRF in embryonic epidermal differentiation
During development, a polarized sheet of epidermal cells undergoes stratification and differentiation to produce the skin barrier. Through mechanisms poorly understood, the process involves adhesion and Notch signaling. To elucidate how epidermal embryogenesis is governed, we conditionally targeted ...
ORGANISM(S): Mus musculus 
2011-01-20 | E-GEOD-25548 | biostudies-arrayexpress
TranscriptomicsEpidermal differentiation: basal vs. suprabasal keratinocytes
In epidermal differentiation basal keratinocytes detach from the basement membrane, stop proliferating, and express a new set of structural proteins and enzymes, which results in an impermeable protein/lipid barrier that protects us. To define the transcriptional changes essential for this process, ...
ORGANISM(S): Homo sapiens 
2010-12-15 | E-GEOD-26059 | biostudies-arrayexpress
GenomicsGrhl3 is essential for epidermal barrier repair from both physical and immune injury, relevance to lesional skin disease
Epidermal barrier repair mechanisms activated in psoriasis lesions are likely involved in limiting the severity of this disease. We show that loss of grainyhead-like 3 (Grhl3), a pro-terminal differentiation factor in the epidermis, is sufficient to trigger greater sensitivity to and delayed resolut...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-52648 | biostudies-arrayexpress
TranscriptomicsConditional keratinocyte-specific ADAM17 knockout in mice alters skin homeostasis
This study investigates the role of ADAM17 (a disintegrin and metalloproteinase 17) in skin homeostasis. Here, we show that mice lacking ADAM17 in keratinocytes have a normal epidermal barrier and skin architecture at birth, but develop pronounced defects in epidermal barrier integrity soon after bi...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-38830 | biostudies-arrayexpress
ProteomicsEffects of CerS4 deletion in murine epidermis on proteome and lipidome
Epidermal deletion of the lipid modifying enzyme CerS4 causes epidermal barrier impairments associated with human skin diseases. Proteomes of Wt newborn and P47 mice were compared in order to identify molecular differences between barrier formation and maintenance. Proteomes of epidermal splits from...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-27 | PXD012220 | Pride
Epidermal barrier Lipid homeostasis Barrier maintenance Barrier formation Cers4 Ceramides 
TranscriptomicsSphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis
Sphingosine 1-phosphate (S1P) is a bioactive lipid whose levels are tightly regulated by its synthesis and degradation. Intracellularly, S1P is dephosphoryled by the actions of two S1P-specific phosphatases, sphingosine 1-phosphate phosphatase 1 and 2. To identify the physiologic functions of S1P p...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-40368 | biostudies-arrayexpress
TranscriptomicsBroad defects in epidermal cornification in atopic dermatitis (AD) identified through genomic analysis
In this study we used genomic profiling to characterize differences in expression of genes related to epidermal growth/differentiation and inflammatory circuits in skin lesions of psoriasis and atopic dermatitis (AD), comparing expression values to normal skin. Skin biopsies were collected from 9 pa...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-16161 | biostudies-arrayexpress
TranscriptomicsExpression changes between loricrin knockout and wildtype P0
The loss of loricrin, a major component of the cornified envelope, results in a delay of epidermal barrier formation. Therefore, the living layers of the epidermis are aberrantly exposed to late-stage amniotic fluid, which may serve as the signal to upregulate genes that functionally compensate for ...
ORGANISM(S): Mus musculus 
2013-06-28 | E-GEOD-41742 | biostudies-arrayexpress
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