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ProteomicsEffects of CerS4 deletion in murine epidermis on proteome and lipidome
Epidermal deletion of the lipid modifying enzyme CerS4 causes epidermal barrier impairments associated with human skin diseases. Proteomes of Wt newborn and P47 mice were compared in order to identify molecular differences between barrier formation and maintenance. Proteomes of epidermal splits from...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-27 | PXD012220 | Pride
Epidermal barrier Lipid homeostasis Barrier maintenance Barrier formation Cers4 Ceramides 
UnknownT-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model.
Not available
S-EPMC8837088 | biostudies-literature
UnknownPhospholipid metabolism-related genotypes of PLA2R1 and CERS4 contribute to nonobese MASLD.
Not available
S-EPMC11155565 | biostudies-literature
UnknownA chemokine-based prognostic model featuring CXCL8, ITGA5, BACE2, CCR7, CERS4, and MEI1 for cervical cancer.
Not available
S-EPMC12828929 | biostudies-literature
OtherLipid Metabolism Alterations Induce PD-L1 Internalization and Signaling to Regulate Breast Cancer Metastasis and Response to Immunotherapy [EXOSC10 RNA-IP-seq]
Programmed death-ligand 1, PD-L1 (CD274), is expressed by cancer cells to facilitate immune evasion. PD-L1 also exerts pro-survival functions in cancer cells, and mechanisms that regulate intracellular PD-L1 signaling remain largely unknown. Here, we report a new mechanism whereby internalization of...
ORGANISM(S): Homo sapiens 
2024-07-07 | GSE250638 | GEO
OtherLipid Metabolism Alterations Induce PD-L1 Internalization and Signaling to Regulate Breast Cancer Metastasis and Response to Immunotherapy [Caprin-1 RNA-IP-seq]
Programmed death-ligand 1, PD-L1 (CD274), is expressed by cancer cells to facilitate immune evasion. PD-L1 also exerts pro-survival functions in cancer cells, and mechanisms that regulate intracellular PD-L1 signaling remain largely unknown. Here, we report a new mechanism whereby internalization of...
ORGANISM(S): Mus musculus 
2024-07-07 | GSE250637 | GEO
ProteomicsAlterations of Ceramide Synthesis Induce PD-L1 Internalization and Signaling to Regulate Tumor Metastasis and Immunotherapy Response
Programmed death-ligand 1, PD-L1 (CD274) facilitates immune evasion and exerts pro-survival functions in cancer cells. Here, we report a new mechanism whereby internalization of PD-L1 in response to alterations of bioactive lipid/ceramide metabolism by ceramide synthase 4 (CerS4) induces sonic-hedge...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD053108 | Pride
Sonic-hedgehog Ceramide Sphingolipid Cers4 Pd-l1 Metastasis Immunotherapy 
ProteomicsComplexome profiling to study consequences of membrane protein complexes in cells with knock down of ceramide synthase 4 and 5 in HCT-116 and Caco-2 cells.
Ceramide synthases are central enzymes of the sphingolipid pathway and are important for the production of sphingolipids of different chain length. Sphingolipids of different chain length impact the physicochemical properties of membranes. Here we investigated by complexome profiling how the expres...
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD030604 | Pride
Lc-msms Complexome profiling 
UnknownCeramide synthase 4 overexpression exerts oncogenic properties in breast cancer.
Not available
S-EPMC10605224 | biostudies-literature
UnknownTGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis.
Not available
S-EPMC5818989 | biostudies-literature
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