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MetabolomicsLipidome Signatures of Metastasis in a Transgenic Mouse Model of Sonic Hedgehog Medulloblastoma.
Not available
ORGANISM(S): Mus musculus 
ST001290 | MetabolomicsWorkbench
TranscriptomicsTranscriptional responses to Sonic Hedgehog pathway stimulation in in vitro derived neural progenitors
The objective of this study was to identify genes regulated by Sonic Hedgehog pathway stimulation in neural progenitors. Paired (parallel culture) triplicates of neuralized embryoid body cultures with and without Shh pathway stimulation (Ag1.3-treatment)
ORGANISM(S): Mus musculus 
2012-12-15 | E-GEOD-42565 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of rat cerebellar granular neuronal precursor cells plated with Sonic Hedgehog (Shh) and then treated with the PKA activator DBA
Cerebellar granular neuronal precursors were plated in presence of Sonic Hedgehog (Shh) for 24h and then treated with the PKA activator Dibutyryl Cyclic Adenosine Monophosphate (DBA) for addittional 24h
ORGANISM(S): Rattus norvegicus 
2008-07-11 | E-MEXP-1668 | biostudies-arrayexpress
ProteomicsParalogue specific TTC30A knockout downregulates Sonic hedgehog signaling
Cilia assembly, maintenance and the localization of signal-transduction proteins necessitate a functioning intraflagellar transport (IFT). The IFT machinery moves cargo along a microtubule scaffold from the proximal to the distal end of the cilium. This anterograde transport is facilitated by a larg...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD044183 | Pride
Ttc30 paralogues Sonic hedgehog signaling Affinity proteomics Ift Pka Cilia 
TranscriptomicsThe miR-17/92 Polycistron Is Up-regulated in Sonic Hedgehog-Driven Medulloblastomas and Induced by N-myc in Sonic Hedgehogâ??Treated Cerebellar Neural Precursors
Medulloblastoma is the most common malignant pediatric brain tumor, and mechanisms underlying its development are poorly understood. We identified recurrent amplification of the miR-17/92 polycistron proto-oncogene in 6% of pediatric medulloblastomas by high-resolution single-nucleotide polymorphism...
ORGANISM(S): Homo sapiens 
2010-04-14 | E-GEOD-21166 | biostudies-arrayexpress
TranscriptomicsExpression data from E11.5 mouse embryonic forelimbs - various mutant conditions or dissected limb domains
Sonic hedgehog (Shh) signals via Gli transcription factors to direct digit number and identity in the vertebrate limb. We have characterized the Gli-dependent cis-regulatory network through a combination of whole genome ChIP-on-chip and transcriptional profiling of the developing mouse limb. In this...
ORGANISM(S): Mus musculus 
2008-09-14 | E-GEOD-11063 | biostudies-arrayexpress
GenomicsSonic Hedgehog inhibitor cyclopamine effect on JAR cells
Sonic Hedgehog inhibitor cyclopamine effect on JAR cells
PRJNA539925 | ENA
TranscriptomicsHepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model
The causative role of activated Hedgehog signaling in liver fibrosis was investigated in vivo. Using hydrodynamics-based transfection, a transgenic mouse model has been developed that expresses Sonic Hedgehog (SHH), a ligand for Hedgehog signaling, in the liver. Levels of hepatic fibrosis and fibros...
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-72758 | biostudies-arrayexpress
TranscriptomicsExpression data from colon fibroblasts treated with Sonic hedgehog homolog (SHH)
Canonical Hedgehog (Hh) signaling regulates the expression of genes that are critical to the patterning and development of a variety of organ systems. In adult, both ligand-dependent and ligand-independent Hh pathway activation are known to promote tumorigenesis. Recent studies have shown that in tu...
ORGANISM(S): Homo sapiens 
2011-05-17 | E-GEOD-29316 | biostudies-arrayexpress
GenomicsA new subgroup of hepatocellular adenomas with sonic hedgehog pathway activation
Hepatocellular adenomas (HCA) are benign liver tumors divided in molecular subtypes characterized by mutations inactivating HNF1A, activating β-catenin or the IL-6/JAK/STAT inflammatory pathway. Molecular analyses of 533 HCA developed in 411 patients identified a new tumor subgroup with Sonic Hedgeh...
EGAS00001002091 | EGA
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