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ProteomicsBiochemically validated structural model of the 15-subunit intraflagellar transport complex IFT-B
Cilia are ubiquitous eukaryotic organelles impotant for cellular motility, signaling, and sensory reception. Cilium formation requires intraflagellar transport of structural and signaling components and involves 22 different proteins organized into intraflagellar transport (IFT) complexes IFT-A and ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-02 | PXD037049 | Pride
Protein structure Intraflagellar transport Cross-linking Proteomics Cilia 
ProteomicsDSSO Crosslinking of Partially Purified IFT-A from Tetrahymena thermophila
DSSO crosslinking data from two Tetrahymena thermophila samples: IEX fractions from chromatography of a cilia extract, and IFT-A-enriched fractions from preparative SEC of cilia extract.
ORGANISM(S): Tetrahymena Thermophila (ncbitaxon:5911) 
2022-03-25 | MSV000089131 | MassIVE
ProteomicsTTC30A and TTC30B redundancy protects IFT complex B integrity and its pivotal role in ciliogenesis
Intraflagellar transport (IFT) is a microtubule-based system that supports the assembly and maintenance of cilia, an essential organelle for development and maintenance of cellular integrity. Dysfunction of IFT was shown to lead to a wide spectrum of disease phenotypes, so called ciliopathies of var...
ORGANISM(S): Homo sapiens (Human) 
2023-12-28 | PXD033614 | Pride
Ift Cilia 
ProteomicsTTC30A and TTC30B redundancy protects IFT complex B integrity and its pivotal role in ciliogenesis
Intraflagellar transport (IFT) is a microtubule-based system that supports the assembly and maintenance of cilia, an essential organelle for development and maintenance of cellular integrity. Dysfunction of IFT was shown to lead to a wide spectrum of disease phenotypes, so called ciliopathies of var...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD034412 | Pride
Ttc30 Cilia Ift-b 
TranscriptomicsAltered Expression of Intraflagellar Transport Genes is Associated with Short Cilia in Smoking and COPD
Study Smoking and COPD are associated with decreased mucociliary clearance and healthy smokers have shorter cilia in the large airway than nonsmokers. Intraflagellar transport (IFT) is the process by which cilia are produced and maintained. We assessed expression of IFT-related genes in smokers and ...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-43939 | biostudies-arrayexpress
ProteomicsExtensive structural rearrangement of intraflagellar transport trains underpins bidirectional cargo transport
Bidirectional transport in cilia is carried out by polymers of the IFTA and IFTB protein complexes, referred to as anterograde and retrograde IFT “trains”. Anterograde trains deliver cargoes from the cell to the ciliary tip, then remodel into retrograde trains for cargo export. We set out to underst...
ORGANISM(S): Chlamydomonas Reinhardtii 
2024-08-21 | PXD049195 | JPOST Repository
ProteomicsExtensive structural rearrangement of intraflagellar transport trains underpins bidirectional cargo transport (Proteomics
Bidirectional transport in cilia is carried out by polymers of the IFTA and IFTB protein complexes, referred to as anterograde and retrograde IFT “trains”. Anterograde trains deliver cargoes from the cell to the ciliary tip, then remodel into retrograde trains for cargo export. We set out to underst...
ORGANISM(S): Chlamydomonas Reinhardtii 
2024-08-21 | PXD049260 | JPOST Repository
UnknownIn vivo imaging shows continued association of several IFT-A, IFT-B and dynein complexes while IFT trains U-turn at the tip.
Not available
S-EPMC8487644 | biostudies-literature
UnknownThe molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains.
Not available
S-EPMC10191852 | biostudies-literature
UnknownStructural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train.
Not available
S-EPMC10023715 | biostudies-literature
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