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ProteomicsBiochemically validated structural model of the 15-subunit intraflagellar transport complex IFT-B
Cilia are ubiquitous eukaryotic organelles impotant for cellular motility, signaling, and sensory reception. Cilium formation requires intraflagellar transport of structural and signaling components and involves 22 different proteins organized into intraflagellar transport (IFT) complexes IFT-A and ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-02 | PXD037049 | Pride
Protein structure Intraflagellar transport Cross-linking Proteomics Cilia 
ProteomicsTTC30A and TTC30B redundancy protects IFT complex B integrity and its pivotal role in ciliogenesis
Intraflagellar transport (IFT) is a microtubule-based system that supports the assembly and maintenance of cilia, an essential organelle for development and maintenance of cellular integrity. Dysfunction of IFT was shown to lead to a wide spectrum of disease phenotypes, so called ciliopathies of var...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD034412 | Pride
Ttc30 Cilia Ift-b 
ProteomicsTTC30A and TTC30B redundancy protects IFT complex B integrity and its pivotal role in ciliogenesis
Intraflagellar transport (IFT) is a microtubule-based system that supports the assembly and maintenance of cilia, an essential organelle for development and maintenance of cellular integrity. Dysfunction of IFT was shown to lead to a wide spectrum of disease phenotypes, so called ciliopathies of var...
ORGANISM(S): Homo sapiens (Human) 
2023-12-28 | PXD033614 | Pride
Ift Cilia 
UnknownThe molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains.
Not available
S-EPMC10191852 | biostudies-literature
UnknownIn vivo imaging shows continued association of several IFT-A, IFT-B and dynein complexes while IFT trains U-turn at the tip.
Not available
S-EPMC8487644 | biostudies-literature
UnknownBiochemical mapping of interactions within the intraflagellar transport (IFT) B core complex: IFT52 binds directly to four other IFT-B subunits.
Not available
S-EPMC3143597 | biostudies-literature
UnknownIntraflagellar transport (IFT) protein IFT25 is a phosphoprotein component of IFT complex B and physically interacts with IFT27 in Chlamydomonas.
Not available
S-EPMC2671599 | biostudies-literature
UnknownCooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import.
Not available
S-EPMC8098818 | biostudies-literature
UnknownAssembly and stability of IFT-B complex and its function in BBSome trafficking.
Not available
S-EPMC9674899 | biostudies-literature
UnknownCharacterization of mouse IFT complex B.
Not available
S-EPMC2753169 | biostudies-literature
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