Epigenetic treatment

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Organisms

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Technology Type

Mass Spectrometry (160)
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Mass spectrometry (14)
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ILLUMINA, Illumina HiSeq 1000 (1)
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ILLUMINA, Illumina HiSeq 2500 (1)
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ESI (1)

Instrument Platform

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- (2)
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2015 (540)
2013 (489)
2014 (476)
2025 (404)
2026 (369)
2016 (331)
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2011 (313)
2023 (281)
2012 (243)
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2021 (205)
2010 (146)
2020 (123)
2018 (118)
2019 (107)
2017 (92)
2009 (50)
2008 (48)
2007 (15)
2006 (7)
2005 (3)
2004 (1)

CHEBI ID

CHEBI:30769 (8)
CHEBI:15741 (8)
CHEBI:15428 (7)
CHEBI:16708 (7)
CHEBI:16335 (7)
CHEBI:17115 (6)
CHEBI:16856 (6)
CHEBI:32816 (6)
CHEBI:30915 (6)
CHEBI:16737 (6)
CHEBI:16015 (6)
CHEBI:15891 (6)
CHEBI:17202 (5)
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CHEBI:22660 (5)
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CHEBI:16643 (5)
CHEBI:16414 (5)
CHEBI:15603 (5)
CHEBI:15354 (5)
CHEBI:15682 (4)
CHEBI:17268 (4)
CHEBI:17148 (4)
CHEBI:17053 (4)
CHEBI:15367 (1)

Metabolite Name

Adenosine (8)
Creatinine (6)
L-Phenylalanine (6)
L-Threonine (5)
Xanthosine (5)
Niacinamide (5)
Taurine (5)
Succinic acid (5)
L-Asparagine (4)
1-Methyladenosine (4)
NADH (4)
Citrate (4)
Thymine (4)
Adenine (4)
Glycine (4)
L-Glutamine (4)
L-Tyrosine (4)
Glutaric acid (4)
Hypoxanthine (4)
L-Proline (4)
L-Isoleucine (4)
L-Tryptophan (4)
Adenine (4)
L-Methionine (4)
Deoxyuridine (4)
L-Valine (4)
Choline (4)
4-Oxoproline (4)
L-Glutamic acid (4)
Fumaric acid (4)

First Public Date

2025 (513)
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2014 (255)
2022 (235)
2021 (216)
2020 (175)
2019 (141)
2018 (134)
2017 (132)
2015 (74)
2016 (53)
2013 (22)

Modelling Approach

Multi-value logic model (1)
Ordinary differential equation model (1)

Study status

Completed (2)
Terminated (1)
Recruiting (1)
Not provided (1)

Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (12)
German Cancer Consortium (DKTK), partner site Freiburg German Cancer Research Center (DKFZ) Foundation under Public Law c/o Department of Urology Zentrale Klinische Forschung (ZKF) Medical Center-University of Freiburg Breisacher Str. 66, 79106 Freiburg, Germany (4)
School of Life Sciences, Tsinghua University, China (2)
Mass Spectrometry/Proteomics Facility, Netherlands Cancer Institute, Amsterdam, Netherlands. (2)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (2)
Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Centro de Biociências e Biotecnologia, Laboratório de Química e Função de Proteínas e Peptídeos, Prédio P5, Sala 228, Bairro Parque Califórnia, Campos dos Goytacazes, RS - CEP: 28013-602 (2)
Shanghai Jiao Tong University (2)
Department of Urology, Emory University School of Medicine, Atlanta, GA, USA (1)
The Gene Lay Institute of Immunology and Inflammation Harvard Medical School and Brigham and Women's Hospital (1)
Claude Asselin, Université de Sherbrooke, Department of immunology and Cell Biology, Faculty of medicine and Health Sciences, Université de Sherbrooke (lab head) (1)
NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing 400016, China; (1)
The University of South Florida (1)
Univ Bordeaux, U1035 INSERM, France (1)
Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, 80802 Munich, Germany Department of Immunobiology, Université de Lausanne, 1066 Epalinges, Switzerland (1)
Assistant Professor, Dept of Obstetrics & Gynaecology, Faculty of Medicine, The Ubiversity of Hong Kong (1)
Quantitative proteomics and metabolomics Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association Hannoversche Str. 28, 10115 Berlin (1)
Helmholtz Zentrum München, Institute of Lung Biology and Disease, Member of the German Center for Lung Research (DZL), Munich, Germany (1)
Dept. of Oncology, University of Oxford, Oxford, OX3 7DQ, UK (1)
Max Planck Institute of Immunobiology and Epigenetics Freiburg, Germany (1)
Head of the Department, Proteomics Core (1)
Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK. (1)
PRISM laboratory, Inserm U1192, University of Lille (1)
Department of Innovative Technologies in Medicine & Dentistry, University of "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy (1)
The Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria (1)
Sun Yat-sen University Cancer Center, Department of Pathology (1)
Department of Cellular and Molecular Pharmacology, University of California, San Francisco (1)
The University of Hong Kong (address: Swire Institute of Marine Science & School of Biological Sciences, Kadoorie Building, Pokfulam Road, Hong Kong SAR) (1)
Department of Molecular Genetics and Cell Biology and Ludwig Center for Metastasis Research, The University of Chicago, Chicago IL (1)
Chemistry Institute, LADETEC, Proteomics Laboratory, UFRJ, RJ, Brazil. (1)
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago IL, USA (1)

Keyword

INCB057643 (1)
Non operative management (1)
Azacitidine (1)
Capecitabina (1)
Oxaliplatino (1)
Pembrolizumab (1)
CRC (1)
Rectal cancer (1)
Neoadjuvant (1)

IsPrivate

False (3)

Submitter Keywords

Not Peer Reviewed (1)

Classification

protozoa (11)
fungi (5)
helminths (1)

Modification

1x(15)N labeled L-valine (1)
N6 (1)

Study type

Transcription profiling by array (858)
ChIP-seq (350)
RNA-seq of coding RNA (333)
Methylation profiling by array (306)
ChIP-chip by tiling array (249)
Methylation profiling by high throughput sequencing (197)
RNA-seq of non coding RNA (56)
Other (47)
Comparative genomic hybridization by array (16)
ChIP-chip by array (13)
Bisulfite-seq (13)
RNA-seq of coding RNA from single cells (12)
Transcription profiling by tiling array (11)
Transcription profiling by RT-PCR (11)
MicroRNA profiling by array (10)
DNA-seq (9)
ATAC-seq (8)
Unknown experiment type (6)
RNA-seq of total RNA (6)
Plant - High-throughput sequencing (5)
Cell line - High-throughput sequencing (5)
Genotyping by array (5)
Cell line - Methylation microarray (2)
Human - Methylation microarray (2)
Cell line - One-color microarray (2)
MicroRNA profiling by high throughput sequencing (2)
Genotyping by high throughput sequencing (2)
RNA-seq of non coding RNA from single cells (1)
Human - Two-color microarray (1)
MicroRNA profiling by high-throughput sequencing (1)

Release Date

2022 (986)
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2014 (686)
2020 (643)
2013 (633)
2016 (630)
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2019 (548)
2018 (456)
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2011 (385)
2012 (338)
2010 (195)
2026 (140)
2009 (85)
2008 (80)
2007 (32)
2006 (19)
2004 (7)
2005 (2)
2003 (2)
2002 (1)
2001 (1)
1999 (1)
1998 (1)

Location

United Kingdom (2)
China (1)
Italy (1)
Spain (1)
Switzerland (1)
United States (1)

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Lactate controls cancer stemness and plasticity through epigenetic regulation.

Tumours arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumours, however, retain some hierarchical organization, maintaining both cancer stem cells (CSCs) and cancer differentiated cells (CDCs). This heterogen...

2025-05-28 | MTBLS11849 | MetaboLights

Reversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies

Not available

ORGANISM(S): Mus musculus

ST001838 | MetabolomicsWorkbench

Multiomics analysis of residual feed intake regulation in calves by intestinal microbiota-mediated epigenetic modifications

Feed efficiency is a critical trait affecting the economic profitability and environmental sustainability of livestock production. Residual Feed Intake (RFI), as a key metric for feed efficiency, effectively reflects differences in energy utilization for maintenance and production. This study aims t...

2026-04-20 | MTBLS14315 | MetaboLights

Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity

Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity, PPI of ZMYND11 in LNCap

ORGANISM(S): Homo Sapiens

2024-08-28 | PXD055421 |

PML-RARa/RXR alters the epigenetic landscape in Acute Promyelocytic Leukemia

Many different molecular mechanisms have been suggested to be associated with PML-RAR dependent transformation of haematopoietic progenitors. Here, we investigated the role of PML-RAR and RXR in the organization of epigenetic structures at a genome-wide level. We identified 2722 high confidence PML-...

ORGANISM(S): Homo sapiens

2009-12-17 | E-GEOD-18886 | biostudies-arrayexpress

Epigenetic events in early breast cancer

Subpopulations of primary Human Mammary Epithelial Cells (HMEC) have the unique ability to escape a period of growth arrest and continue to proliferate. These cells, called post-selection or variant cells (vHMEC), share features with premalignant breast cancer lesions, including p16INK4A promoter h...

ORGANISM(S): Homo sapiens

2010-05-26 | E-GEOD-8007 | biostudies-arrayexpress

MRNA expression data from human breast cancer cell lines after demethylation treatment.

The contribution of aberrant DNA methylation and the downstream effects in tumorogenesis through silencing of tumor suppressor genes (TSGs) and microRNAs has been investigated. Since these epigenetic alterations can be reversed, we investigated the effects of the epigenetic therapy in breast cancer ...

ORGANISM(S): Homo sapiens

2012-01-24 | E-GEOD-28968 | biostudies-arrayexpress

Changes in gene expression after epigentic targeted therapy in T-cell prolymphocytic leukemia (T-PLL)

Epigenetic therapy overcame alemtuzumab resistance in patients with relapsed T-cell prolymphocytic leukemia and induced the expression of treatment related genes. Method: patient PBMCs from Ficoll, normal patient PBMCS enriched for CD3+/CD8+ or CD3+/CD8+/CD45RA+/CCR7- were extracted in Trizol. Con...

ORGANISM(S): Homo sapiens

2015-07-08 | E-GEOD-67368 | biostudies-arrayexpress

Epigenetic therapy for Friedreich ataxia.

We set out to investigate whether a histone deacetylase inhibitor (HDACi) would be effective in an in vitro model for the neurodegenerative disease Friedreich ataxia (FRDA) and to evaluate safety and surrogate markers of efficacy in a phase I clinical trial in patients. In the neuronal cell model, H...

ORGANISM(S): Homo sapiens

2015-01-29 | E-GEOD-65399 | biostudies-arrayexpress

Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer.

Not available

S-EPMC4811494 | biostudies-literature

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