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MetabolomicsVitamin D deficiency disrupts a host–microbiota bile acid axis in aged mice to drive Faecalibaculum rodentium expansion and intestinal epithelial barrier dysfunction
This study investigated how vitamin D deficiency alters the fecal metabolome and bile acid metabolism in mice and evaluated the contribution of Faecalibaculum rodentium bile salt hydrolase activity to intestinal epithelial barrier dysfunction. Two complementary mouse experiments were included. In th...
2026-08-07 | MTBLS15279 | MetaboLights
MetabolomicsF-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis
Intestinal barrier dysfunction is a hallmark of gastrointestinal disorders, including inflammatory bowel diseases (IBD). In IBD, the disruption of the gut barrier causes liquid loss and persistent immune response. Understanding the cellular events underlying epithelial barrier disruption during chro...
2026-04-01 | MTBLS14166 | MetaboLights
MetabolomicsMultiomic analysis reveals that polyamines alter G. vaginalis-induced cervicovaginal epithelial cell dysfunction

An anaerobe-dominant, Lactobacillus-deplete cervicovaginal microbiome is associated with adverse reproductive outcomes. Gardnerella vaginalis, a cervicovaginal anaerobe, alters cervicovaginal epithelial cell function, resulting in immune activation and barrier breakdow...

2026-02-10 | MTBLS13885 | MetaboLights
MetabolomicsDual Effects of Fasting on Gut Microbiota and Metabolism: Protective Adaptation versus Barrier Dysfunction Risks
Fasting is increasingly recognized as a metabolic intervention that reshapes gut microbiota and host metabolism, but its duration-dependent effects on intestinal epithelial integrity remain incompletely understood. In this study, we compared ad libitum feeding, 12 h fasting, and 24 h fasting in male...
2026-07-20 | MTBLS15098 | MetaboLights
MetabolomicsComparative metabolomics analysis of bronchial epithelium during barrier establishment after allergen exposure

BACKGROUND: Several studies have shown a correlation between an altered metabolome and respiratory allergies. The epithelial barrier hypothesis proposes that an epithelial barrier dysfunction can result in allergic diseases development. Der p 1 allergen from house dust mite is a...

2023-08-22 | MTBLS1755 | MetaboLights
MetabolomicsIntestinal TM6SF2 Protects Against Metabolic Dysfunction-associated Steatohepatitis through the Gut-Liver Axis

Transmembrane-6 superfamily member 2 (TM6SF2) regulates hepatic fat metabolism and is closely associated with metabolic dysfunction-associated steatohepatitis (MASH). MASH involves genetic predisposition and gut microbiota alteration, yet the role of host-microbes interaction in disease developme...

2024-10-08 | MTBLS11004 | MetaboLights
ProteomicsLack of intestinal Mucin-1 impairs intestinal epithelial barrier and promotes metabolic dysfunction-associated steatotic liver disease in mice
Accumulating evidence suggests that a compromised intestinal epithelial barrier (IEB) contributes to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD); however, the exact mechanisms remain unclear. Here we reveal that intestinal mucin 1 (MUC1) levels and glycosylati...
ORGANISM(S): Homo sapiens (Human) 
2025-12-14 | PXD066810 | Pride
Masld  intestinal epithelial barrier  muc1  glycosylation  β-catenin 
TranscriptomicsDistinctions between the stasis and telomere attrition senescence barriers in cultured human mammary epithelial cells
Molecular distinctions between the stasis and telomere attrition senescence barriers in cultured human mammary epithelial cells Normal human epithelial cells in culture have generally shown a limited proliferative potential of ~10-40 population doublings before encountering a stress-associated sene...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-16058 | biostudies-arrayexpress
TranscriptomicsExpression data from HT29 intestinal epithelial cell line
The study recapitulates, through in vitro micropatterned co-cultures, interactions between HIV-infected T-lymphocytes and intestinal epithelial cells in order to investigate the mechanisms underlying the disruption of normal epithelial cell and barrier function during HIV infection. The co-culture m...
ORGANISM(S): Homo sapiens 
2014-03-22 | E-GEOD-56090 | biostudies-arrayexpress
UnknownIntestinal Epithelial Digestive, Transport, and Barrier Protein Expression Is Increased in Environmental Enteric Dysfunction.
Not available
S-EPMC10121737 | biostudies-literature
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