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ProteomicsEPLIN-Beta is a novel substrate of ornithine decarboxylase antizyme 1, mediating cellular migration
Polyamines promote cellular proliferation, and their levels are controlled by ornithine decarboxylase antizyme 1 (Az1), through the proteasome-mediated, ubiquitin-independent degradation of ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis. Az1-mediated degradation of...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD039865 | Pride
Ubiquitin-independent degradation Antizyme Cell migration Eplin/lima1 
UnknownEPLIN, a Putative Tumour Suppressor in Colorectal Cancer, Implications in Drug Resistance.
Not available
S-EPMC9736569 | biostudies-literature
TranscriptomicsIdentification of EPLIN as a novel MYCN-independent target in neuroblastoma and medulloblastoma
Neuroblastoma and medulloblastoma are the most common solid tumors in children, with MYC(N) proto-oncogene amplification serving as a key marker of aggressive disease and poor treatment outcomes. However, the complex nature of the challenging MYC(N) protein underscores the urgent need for additional...
ORGANISM(S): Homo sapiens 
2025-07-30 | GSE275538 | GEO
TranscriptomicsRNA-seq of murine ES cells with Lima1 knockout, murine EpiS cells with Lima1 overexpression and human iPS cells with LIMA1 overexpression
In chimera assays, murine naïve embryonic stem (ES) cells usually produce better chimeras than the more primed epiblast-derived stem (EpiS) cells. Overexpression of the cytoskeleton-associated protein LIMA1/EPLIN in EpiS cells improves the rate of successful chimeras, while the knockout of LIMA1 in ...
ORGANISM(S): Homo sapiens 
2021-12-16 | E-MTAB-10301 | biostudies-arrayexpress
UnknownA specific role for endothelial EPLIN-isoform-regulated actin dynamics in neutrophil transmigration.
Not available
S-EPMC12053001 | biostudies-literature
UnknownEplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome.
Not available
S-EPMC2553413 | biostudies-literature
UnknownEPLIN-β is a novel substrate of ornithine decarboxylase antizyme 1 and mediates cellular migration.
Not available
S-EPMC10281260 | biostudies-literature
UnknownEPLIN, a prospective oncogenic molecule with contribution to growth, migration and drug resistance in pancreatic cancer.
Not available
S-EPMC11680852 | biostudies-literature
UnknownThe concerted action of SEPT9 and EPLIN modulates the adhesion and migration of human fibroblasts.
Not available
S-EPMC11077590 | biostudies-literature
UnknownThe focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites.
Not available
S-EPMC4342583 | biostudies-literature
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