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TranscriptomicsRNA-seq of murine ES cells with Lima1 knockout, murine EpiS cells with Lima1 overexpression and human iPS cells with LIMA1 overexpression
In chimera assays, murine naïve embryonic stem (ES) cells usually produce better chimeras than the more primed epiblast-derived stem (EpiS) cells. Overexpression of the cytoskeleton-associated protein LIMA1/EPLIN in EpiS cells improves the rate of successful chimeras, while the knockout of LIMA1 in ...
ORGANISM(S): Homo sapiens 
2021-12-16 | E-MTAB-10301 | biostudies-arrayexpress
ProteomicsEPLIN-Beta is a novel substrate of ornithine decarboxylase antizyme 1, mediating cellular migration
Polyamines promote cellular proliferation, and their levels are controlled by ornithine decarboxylase antizyme 1 (Az1), through the proteasome-mediated, ubiquitin-independent degradation of ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis. Az1-mediated degradation of...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD039865 | Pride
Ubiquitin-independent degradation Antizyme Cell migration Eplin/lima1 
UnknownEPLIN-β is a novel substrate of ornithine decarboxylase antizyme 1 and mediates cellular migration.
Not available
S-EPMC10281260 | biostudies-literature
GenomicsRNA-seq of murine ES cells with Lima1 knockout, murine EpiS cells with Lima1 overexpression and human iPS cells with LIMA1 overexpression
RNA-seq of murine ES cells with Lima1 knockout, murine EpiS cells with Lima1 overexpression and human iPS cells with LIMA1 overexpression
PRJEB44077 | ENA
UnknownThe focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites.
Not available
S-EPMC4342583 | biostudies-literature
UnknownNovel interactors and a role for supervillin in early cytokinesis.
Not available
S-EPMC2901166 | biostudies-literature
ProteomicsLima1 mediates the pluripotency control of membrane dynamics and cellular metabolism
Lima1 is an extensively studied prognostic marker of malignancy and is also considered to be a tumour suppressor, but its role in a developmental context of non-transformed cells is poorly understood. Here, we characterised the expression pattern and examined the function of Lima1 in mouse embryos a...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-16 | PXD025293 | Pride
Lc-msms Stem cells Proteomics Pluripotency Development Lim domain and actin binding 1 Lima1 Eplin 
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