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TranscriptomicsMicroRNA expression profile of non-Hodgkin B-cell lymphomas, reactive lymph nodes, pure B and T cell, lymphoblastoid cell lines and mononucleosis
MicroRNAs expression profile was acquired in 99 frozen tissues corresponding to 14 Burkitt's lymphoma, 17 diffuse large B-cell lymphoma, 29 follicular lymphoma, 19 mantle cell lymphoma, 8 primary mediastinal B-cell lymphoma and 12 lymph nodes. Additionally, we performed microRNA expression profile o...
ORGANISM(S): Homo sapiens 
2017-08-20 | E-MTAB-6035 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of chemokines and chemokine receptors on B-cells in chronically HIV-1 infected patients
From the analysis of all genes included in the array a number of individual genes were identified as dys-regulated in HIV-1 infected patients compared to healthy controls. In particular, increased CXCL13 expression in all individual patient samples. Abstract from publication: HIV-1 infection is ass...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-12597 | biostudies-arrayexpress
TranscriptomicsDrosophila melanogaster developmental timecourse: wild type, eve, ftz
Transcriptional profiling of developmentally staged D. mel. Embryos for three genotypes: wild type, eve3 and ftz11 For additional information, please see Liu et al., 2009. Abstract: We constructed a large-scale functional network model in Drosophila melanogaster built around two key transcription fa...
ORGANISM(S): Drosophila melanogaster 
2008-12-30 | E-GEOD-14086 | biostudies-arrayexpress
TranscriptomicsGenetic analysis reveals a longevity associated protein modulating endothelial function and angiogenesis
Transcriptome analysis in HEK293T transfected with plasmid carrying different isoforms of BPIFB4 gene. This gene was previously associated with exceptional longevity in a GWAS study performed on three different populations. Results indicate an up-regulation of stress response genes and proteostasis ...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-63912 | biostudies-arrayexpress
TranscriptomicsArabidopsis thaliana Growth is Negatively Regulated by the Class III Peroxidase AtPrx71 during Development and in Response to Cell Wall Damage
The cell wall is a crucial structure in plant cells, and modifications in its composition often have a major impact on growth and development. However, the molecular mechanisms responsible for the negative effects of cell wall alterations on plant growth are largely unknown. It was previously shown ...
ORGANISM(S): Arabidopsis thaliana 
2016-01-06 | E-GEOD-66980 | biostudies-arrayexpress
TranscriptomicsING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth
ING proteins play an essential role in the control of a variety of cellular functions whose deregulation is associated with tumor formation and dissemination, such as proliferation, apoptosis, senescence or invasion. Accordingly, loss of function of ING proteins is a frequent event in many types of...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-42412 | biostudies-arrayexpress
TranscriptomicsTesticular gene expression profiles in infertile patients with AZFc deletions of the Y chromosome
In the present study we carried out testicular gene expression profiling of patients with AZFc microdeletion, idiopathic infertility and normal spermatogenesis, in order to identify up- and downregulated genes in the different conditions, and to verify the presence of specific molecular pathways le...
ORGANISM(S): Homo sapiens 
2010-10-04 | E-GEOD-14310 | biostudies-arrayexpress
TranscriptomicsWilliams-Beuren syndrome: typical deletions versus atypical deletions of the 7q11.23 region
We have performed comparative transcriptome profile from lymphoblastoid cell lines from four Williams-Beuren syndrome patients and two patients with partial deletions of the region. The goal was to find deregulated genes specifically in WBS versus atypical deletions, and to determine the biological ...
ORGANISM(S): Homo sapiens 
2010-09-09 | E-GEOD-18188 | biostudies-arrayexpress
TranscriptomicsRelevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia (expression)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by chromosomal aberrations of prognostic significance. Recent studies showed that gain of chromosome 2p is a recurrent lesion in CLL. We investigated the 2p gain and its relationship with prognostic biomarkers in ...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-38611 | biostudies-arrayexpress
TranscriptomicsAngio-modulation in endothelial cells: an unexpected role of desmoglein-2 in regulating actin dynamics and its relevance to angiogenesis deregulation in systemic sclerosis
Gene expression study of DSG2 silenced human microvascular endothelial cells Affymetrix GeneChip Human Genome U133 Plus 2.0 Array were used to examine differentially expressed genes between normal microvascular endothelial cells and DSG2 silenced microvascular endothelial cells
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-21547 | biostudies-arrayexpress
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