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MetabolomicsTargeted metabolomic profiling of myocardial remodeling after STEMI

Early detection of myocardial remodeling is essential for optimizing outcomes in patients with ST-segment elevation myocardial infarction (STEMI). However, reliable biomarkers for predicting STEMI myocardial remodeling remain scarce.

Targeted metabolomic profiling was performed on plasma ...

2025-09-02 | MTBLS10634 | MetaboLights
MetabolomicsHuman Cytomegalovirus pUL37x1 is Important to Remodeling of Host Lipid Metabolism
Human cytomegalovirus (HCMV) replication requires host metabolism. Infection alters the activity in multiple metabolic pathways, including increasing fatty acid elongation and lipid synthesis. The virus-host interactions regulating the metabolic changes associated with replication are essential to i...
2020-06-26 | MTBLS1073 | MetaboLights
ProteomicsGlobal proteome remodeling during ER stress involves Hac1-driven expression of long undecoded transcript isoforms
Cellular stress responses often require transcription-based activation of gene expression to promote cellular adaptation. Whether general mechanisms exist for stress-responsive gene down-regulation is less clear. A recently defined mechanism enables both up- and down-regulation of protein levels for...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2018-06-12 | MSV000082454 | MassIVE
MetabolomicsTear lipidomics profiling reveals inflammatory dry eye disease-associated lipid metabolic remodeling at the ocular surface
This study aimed to investigate whether inflammatory dry eye disease (DED) is accompanied by abnormal lipid metabolic remodeling at the ocular surface. Tear samples were collected from patients with DED and matched healthy controls. Lipidomics profiling was performed using LC–MS/MS with a standardiz...
2026-04-03 | MTBLS14218 | MetaboLights
MetabolomicsMulti-omics reveals the DR5-FXR-CHPT1 axis governs hepatocyte pyroptosis via glycerophospholipid remodeling after major partial hepatectomy
Acute liver injury following major partial hepatectomy (PHx), manifesting as small-for-size syndrome (SFSS) and post-hepatectomy liver failure (PHLF), carries high mortality. However, the key mechanisms underlying irreversible remnant liver injury and cell death remain poorly understood, particularl...
2026-08-16 | MTBLS14980 | MetaboLights
MetabolomicsMuscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males

Reduced estrogen action is associated with obesity and insulin resistance. However, the cell and tissue-specific actions of estradiol in maintaining metabolic health remain inadequately understood, especially in men. We observed that skeletal muscle ESR1/Esr1 (encodes estrogen receptor α) is posi...

2025-04-09 | MTBLS914 | MetaboLights
TranscriptomicsStress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Distinct ER Proteostasis Environments [HEK293DYG]
The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6. The functional consequences of these transcription factors for ER proteostasis remain poorly defined. Here, we describe methodology that enabl...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-44950 | biostudies-arrayexpress
ProteomicsExtracellular Signals Induce Dynamic ER Remodeling through TAT1-dependent Microtubule Acetylation
Dynamic changes in the endoplasmic reticulum (ER) morphology are central to maintaining cellular homeostasis. Microtubules (MT) facilitate the continuous remodeling of the ER network into sheets and tubules by coordinating with many ER-shaping protein complexes, although how this process is controll...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD045865 | Pride
Bok Atat1 Microtubules Tak1 Endoplasmic reticulum 
TranscriptomicsStress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Distinct ER Proteostasis Environments [HEK293DAX]
The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6. The functional consequences of these transcription factors for ER proteostasis remain poorly defined. Here, we describe methodology that enabl...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-44949 | biostudies-arrayexpress
GenomicsTranslocon remodeling during protein synthesis at the ER
Translocon remodeling during protein synthesis at the ER
PRJNA1265091 | ENA
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