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TranscriptomicsNuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance
The nuclear receptor TAK1/TR4/NR2C2 is expressed in several tissues that are important in the control of energy homeostasis. TAK1-deficient (TAK1-/-) mice are resistant to the development of age- and high fat diet (HFD)-induced metabolic syndrome. Biochemical analysis showed significantly lower hepa...
ORGANISM(S): Mus musculus 
2010-09-30 | E-GEOD-21903 | biostudies-arrayexpress
TranscriptomicsTranslation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation
Macrophage activation by bacterial lipopolysaccharides (LPS) is induced through Toll-like receptor 4 (TLR4). The synthesis and activity of TLR4 downstream signalling molecules modulates the expression of pro- and anti-inflammatory cytokines. To address the impact of post-transcriptional regulation o...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-48463 | biostudies-arrayexpress
TranscriptomicsIdentification of genes that are regulated by TAK1 in human cutaneous T cell lymphoma HuT-102 cells
We previously reported that human T cell lymphotropic virus 1 (HTLV-1) Tax oncoprotein constitutively activates TAK1. Here, we established Tax-positive HuT-102 cells stably downregulated TAK1 expression by short-hairpin RNA (HuT-shTAK1 cells), and investigated the physiological function of TAK1. Mic...
ORGANISM(S): Homo sapiens 
2009-08-18 | E-GEOD-16219 | biostudies-arrayexpress
ProteomicsA mass spectrometry analysis of the TAK1 protein complex in Jurkat T cells.
Negative regulation of immunoreceptor signaling is required for preventing hyperimmune activation and maintaining immune homeostasis. The roles of p38IP in immunoreceptor signaling remain unclear. Here, we show that p38IP suppresses T cell receptor (TCR)/LPS-activated NF-κB and p38 by targeting TAK1...
ORGANISM(S): Homo sapiens (Human) 
2020-04-30 | PXD018330 | Pride
Tak1 Human Jurkat t cells 
TranscriptomicsGene expression profile of WT and TAK1 KO livers.
The effect of ablation of Tak1 gene in the liver was characterized. RNA was extracted from 1-month-old WT and hepatocyte specific TAK1-deleted mice
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-51962 | biostudies-arrayexpress
TranscriptomicsTAK1-dependent checkpoint in dendritic cell survival regulates immune homeostasis and function
Homeostatic control of dendritic cell (DC) survival is crucial for a productive adaptive immune response, but the molecular mechanism is not well defined. Moreover, how DCs influence homeostasis of the immune system under steady state remains unclear. Combining DC-specific and inducible deletion sys...
ORGANISM(S): Mus musculus 
2012-01-23 | E-GEOD-34417 | biostudies-arrayexpress
Proteomicshuman H. pylori induced TAK1/TAB1 interactomics
Study of dynamic changes in TAK1/TAB1 complex formation after H. pylori infection in human epithelial cells
ORGANISM(S): Homo sapiens (Human) 
2017-12-06 | PXD007632 | Pride
Tab1 H. pylori infection Interactomics Tak1 Human Epithelial cells 
TranscriptomicsTranscription profiling of mouse wild-type and B cell-specific TAK1-deficient B cells to elucidate how TAK1 regulates BCR-mediated proliferative response
BCR-induced gene expression profile in wild-type and B cell-specific TAK1-deficient B cells; to elucidate how TAK1 regulates BCR-mediated proliferative response Experiment Overall Design: Purified splenic B cells (CD43 negative) were treated with or without anti-IgM (20 micloG/mL) for 4 h. Total RNA...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3065 | biostudies-arrayexpress
ProteomicsThe innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for post-translational modifications by host and pathogen
TGF-β Activated Kinase 1 (TAK1) is a critical signaling hub responsible for translating antigen binding signals to immune receptors for the activation of the AP-1 and NF-κB master transcriptional programs. Despite its importance, known substrates of TAK1 are limited to kinases of the MAPK and IKK fa...
ORGANISM(S): Homo sapiens (Human) 
2016-07-19 | PXD004213 | Pride
Kinase Covalent capture Kinase substrates Analog specific kinase 
ProteomicsAnalysis of YAP1 phosphorylation sites induced by TAK1
This study aims at determining which YAP residues are phosphorylated by TAK1.
ORGANISM(S): Homo sapiens (Human) 
2018-11-04 | PXD011256 | Pride
Human 
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