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TranscriptomicsERK5 Regulates Muscle Cell Fusion through Klf Transcription Factors
In skeletal muscle differentiation, muscle-specific genes are regulated by two groups of transcription factors, the MyoD and MEF2 families, which work together to drive the differentiation process. Here we show that ERK5 regulates muscle cell fusion through Klf transcription factors. The inhibition ...
ORGANISM(S): Mus musculus 
2011-02-21 | E-GEOD-25827 | biostudies-arrayexpress
TranscriptomicsNovel Roles fro ERK5 and Cofiin as Critical Mediators Linking Estrogen Receptor α-Driven Transcription, Actin Reorganization and Invasiveness in Breast cancer
Cancer cell motility and invasiveness are fundamental characteristics of the malignant phenotype and are regulated through diverse signaling networks involving kinases and transcription factors. In this study, we identify a nuclear hormone receptor (ERα)-protein kinase (ERK5)-cofilin (CFL1) network ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-53394 | biostudies-arrayexpress
TranscriptomicsPKCzeta-mediated Gaq stimulation of the ERK5 pathway is involved in cardiac hypertrophy
Background: Gq-coupled G protein-coupled receptors (GPCR) mediate the actions of a variety of messengers that are key regulators of cardiovascular function. Enhanced Gaq-mediated signaling plays an important role in cardiac hypertrophy and in the transition to heart failure. We have recently describ...
ORGANISM(S): Mus musculus 
2012-01-10 | E-GEOD-29145 | biostudies-arrayexpress
ProteomicsA gatekeeper residue controls transcriptional activity of the extracellular signal-regulated protein kinase 5 (ERK5) through molecular interactions with the C terminal tail.
We analyzed the interactome of the kinase ERK5 and its mutant Y733E in HeLa cells.
ORGANISM(S): Homo sapiens (Human) 
2020-01-31 | PXD014028 | Pride
Erk5 Human 
ProteomicsAcute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation
Over the past few decades, interest in the role that extracellular signal-regulated kinase 5 (ERK5) plays in various diseases, particularly cancer and inflammation, has grown. Phenotypes observed from genetic knockdown or deletion of ERK5 suggested that targeting ERK5 could have therapeutic potentia...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD036104 | Pride
Targeted protein degradation Erk5 Degrader 
ProteomicsAcute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation
Over the past few decades, interest in the role that extracellular signal-regulated kinase 5 (ERK5) plays in various diseases, particularly cancer and inflammation, has grown. Phenotypes observed from genetic knockdown or deletion of ERK5 suggested that targeting ERK5 could have therapeutic potentia...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD036105 | Pride
Targeted protein degradation Erk5 Degrader 
TranscriptomicsExpression data from mesothelial (LP9) and mesothelioma cells (HMESO) inhibited for extracellular-regulated kinase (ERK) 1, 2, or 5
Extracellular-regulated kinases (ERK1/2 and 5) are known to play important roles in growth and drug resistance of various cancers. Here we show roles of inhibition of ERK1, ERK2, or ERK5 on gene expression profiles of epithelioid malignant mesothelioma (MM) cells (HMESO). Untransfected human mesothe...
ORGANISM(S): Homo sapiens 
2010-05-08 | E-GEOD-21750 | biostudies-arrayexpress
TranscriptomicsHuman Toll-Like Receptors Pathway Array Data
Endothelial cell (EC) Toll-like receptor 2 (TLR2) activation upregulates the expression of inflammatory mediators and of TLR2 itself, and modulates important endothelial functions, including coagulation and permeability. We defined TLR2 signaling pathways in ECs, and tested the hypothesis that TLR2 ...
ORGANISM(S): Homo sapiens 
2011-11-04 | E-GEOD-33449 | biostudies-arrayexpress
ProteomicsThe ERK5 signalling pathway employs a KLF2-ZSCAN4 auto-regulatory module to induce embryonic 2-cell stage genes
The ERK5 MAP kinase signalling pathway was recently discovered as a driver of naïve pluripotency in mouse Embryonic Stem Cells (mESCs). However, the molecular functions of ERK5 in mESCs have not been investigated. Here, we employ combinatorial mESC proteomics to identify ERK5 target genes and substr...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-29 | PXD010581 | Pride
Mass spectrometry Phosphoproteomic Tmt Erk5 
GenomicsWhole transcriptome analysis of endometroid cell lines after ERK5 inhibition
Whole transcriptome analysis of endometroid cell lines after ERK5 inhibition
PRJNA1001389 | ENA
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