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ProteomicsDiscovering the novel role of the S-adenosyl methionine synthetase SAMS-1 in mediating mitochondrial homeostasis during aging
Current worldwide demographics came to the point of the prevalence of people of middle age when the majority of age-related disease start to occur. The existing strategies (dietary and pharmacological interventions) are mostly tested or include treatment starting from young age to promote healthy ag...
ORGANISM(S): Caenorhabditis elegans 
2026-02-23 | PXD024180 | Pride
Mitochondria Aging 
ProteomicsMetformin treatment initiated late in life impairs systemic energy homeostasis and reduces life span by acting in synergy with age-linked mitochondrial dysfunction
Metformin is a type 2 diabetes medication which extends life span across species when given from young adulthood onwards; late life effects of metformin are not well understood. Here we used C. elegans to investigate the outcome of metformin treatment initiated late in life. We found that, contrary ...
ORGANISM(S): Caenorhabditis elegans 
2020-09-21 | PXD011579 | Pride
Energy homeostasis Mitochondrial dysfunction Metformin Ageing 
TranscriptomicsDAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage [N2, daf-2, daf-16, daf-2;daf-16]
Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature aging. It remains poorly understood how DNA damage responses function during organismal development and maintain tissue functionality when DNA damage accumulates wi...
ORGANISM(S): Caenorhabditis elegans 
2014-11-18 | E-GEOD-51162 | biostudies-arrayexpress
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