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MetabolomicsUntargeted metabolomics data from low and high responders to metformin
This study compares the untargeted metabolomic profiles of individuals with low and high responses to metformin. The aim is to identify differential metabolites and metabolic pathways associated with variations in treatment response, thereby providing insights into the metabolic mechanisms underlyin...
2026-09-30 | MTBLS15473 | MetaboLights
MetabolomicsAnalysis of glucose-independent metabolic pathways associated with anti-proliferative effect of metformin and their reversibility in liver cancer cells

Several studies indicated anti-cancer effects of metformin in liver cancer. This was attributed to the activation of LKB-AMPK axis, which is associated with anti-hyperglycaemic effect and cytotoxicity. However, glucose- and central carbon-independent effects of metformin ...

2024-05-22 | MTBLS7760 | MetaboLights
TranscriptomicsExpression data from mouse liver treated with metformin
Optimal treatment for nonalcoholic steatohepatitis (NASH) has not yet been established, particularly for individuals without diabetes. We examined the effects of metformin, commonly used to treat patients with type 2 diabetes, on liver pathology in a non-diabetic NASH mouse model. Eight-week-old C57...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-35961 | biostudies-arrayexpress
MetabolomicsCombined Mesenchymal Stem Cells and Metformin Therapy Modulates Key Macromolecular Pathways in Pulmonary Fibrosis: Evidence from Untargeted Metabolomics

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. Current treatment options remain limited, driving interest in novel therapeutic approaches. Mesenchymal stem cells (MSCs) possess immunomodulatory and regenerative properties, while metformin, traditionally ...

2025-08-25 | MTBLS12893 | MetaboLights
TranscriptomicsTranscription profiling of the effect of metformin (50mg/kg,400mg/kg) on gene expression in livers of db/db mice
Effect of metformin (50mg/kg,400mg/kg) on gene expression in livers of db/db mice.
ORGANISM(S): Mus musculus 
2006-11-18 | E-MEXP-490 | biostudies-arrayexpress
TranscriptomicsInvestigation of placental DNA methylation in obese women exposed to Metformin during pregnancy
Maternal obesity in pregnancy is associated with increased birth-weight, obesity and premature mortality in adult offspring. The Effect of Metformin on Maternal and Fetal Outcomes in Pregnant Obese Women (EMPOWaR) trial was a randomised, double-blind, placebo-controlled trial carried out to determin...
ORGANISM(S): Homo sapiens 
2018-11-01 | E-MTAB-6421 | biostudies-arrayexpress
TranscriptomicsInvestigation of placental gene expression in obese women exposed to Metformin during pregnancy
Maternal obesity in pregnancy is associated with increased birth-weight, obesity and premature mortality in adult offspring. The Effect of Metformin on Maternal and Fetal Outcomes in Pregnant Obese Women (EMPOWaR) trial was a randomised, double-blind, placebo-controlled trial carried out to determin...
ORGANISM(S): Homo sapiens 
2019-01-31 | E-MTAB-6418 | biostudies-arrayexpress
TranscriptomicsPleiotropic effects of metformin on inflammation, oxidative and dicarbonyl stress in transgenic spontaneously hypertensive rats expressing human C-reactive protein.
Inflammation, oxidative and dicarbonyl stress play important roles in the pathophysiology of type 2 diabetes. Metformin is the first-line drug of choice for the treatment of type 2 diabetes because it effectively suppresses gluconeogenesis in the liver, however, its “pleiotropic“ effects remain cont...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-MTAB-3791 | biostudies-arrayexpress
TranscriptomicsStudy of microRNA associated with metforminM-bM-^@M-^Ys anti-tumor effect
The miRNAs expression was markedly altered with the treatment of metformin in vitro and in vivo and various miRNAs induced by metformin also may contribute to tumor growth in vitro and in vivo. Using a custom microarray platform, we analyzed the expression levels of 985 human miRNA probes in the cel...
ORGANISM(S): Homo sapiens 
2012-04-04 | E-GEOD-30289 | biostudies-arrayexpress
MetabolomicsMetformin effects on liver and kidney tissue
Not available
ORGANISM(S): Mus musculus 
ST000340 | MetabolomicsWorkbench
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