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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
ProteomicsProteome Analysis of Actinoplanes sp. SE50/110
The acarviose metabolite acarbose is an a glucosidase inhibitor produced by Actinoplanes sp. SE50/110. It is medically important because it is used in the treatment of type 2 diabetes. In this work a comprehensive proteome analysis of Actinoplanes sp. SE50/110 was carried out. The associated txt and...
ORGANISM(S): Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110) 
2015-10-21 | PXD001497 | Pride
Actinoplanes sp. se50/110 
ProteomicsA novel mobile genomic island: introducing ‘cephalosporinase morons’ in Enterobacteriaceae
The exchange of mobile genomic islands (MGIs) between microorganisms is often mediated by phages. As a consequence, not only phage genes are transferred, but also genes that have no particular function in the phage's lysogenic cycle. If they provide benefits to the phage's host, such genes are refer...
ORGANISM(S): Enterobacter cloacae 
2018-08-21 | PXD007113 | Pride
"cephalosporin resistance " Enterobacteriaceae "mobile genomic islands " 
ProteomicsImpact of moderate temperature changes on Neisseria meningitidis adhesive phenotypes and proteome
Neisseria meningitidis, the meningococcus, bears the potential of life-threatening invasive diseases, but it usually colonizes the nasopharynx without causing any symptoms. Within the nasopharynx, Neisseria meningitidis must face temperature changes depending on the ambient air temperature. Indeed, ...
ORGANISM(S): Neisseria meningitidis serogroup B (strain MC58) 
2016-10-10 | PXD003690 | Pride
Temperature Sigma e Adhesion Biofilm Proteome Meningococcus 
ProteomicsThe Extracellular Proteome and Citrullinome of the Oral Pathogen Porphyromonas gingivalis
Porphyrmonas gingivalis is an oral pathogen associated with the inflammatory disease periodontitis. The colonization of oral epithelial surfaces by P. gingivalis may also lead to the autoimmune disease rheumatoid arthritis. One of the hallmarks of rheumatoid arthritis is the loss of tolerance agains...
ORGANISM(S): Porphyromonas gingivalis 
2018-02-28 | PXD003444 | Pride
Porphyromonas gingivalis Mass spectrometry Citrullination Exoproteome Rheumatoid arthritis Periodontitis 
ProteomicsEvolution of an outbreak of meningococcal disease among men who have sex with men
Neisseria meningitidis (meningococcus) is usually transmitted via respiratory droplets, whereas its close relative, the gonococcus is sexually transmitted. Invasive meningococcal disease due to isolates of serogroup C increased in Europe and the United States among men who have sex with men (MSM). ...
ORGANISM(S): Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18) 
2016-05-18 | PXD001498 | Pride
Evolution Ania Neisseria meningitidis 
TranscriptomicsA comprehensive gene expression analysis of resistance formation upon metronomic cyclophosphamide therapy
Resistance formation is one of the major hurdles in cancer therapy. Metronomic anti-angiogenic treatment of xenografted prostate cancer tumors in SCID mice with cyclophosphamide (CPA) results in the appearance of resistant tumors. To investigate the complex molecular changes occurring during resista...
ORGANISM(S): Homo sapiens 
2013-01-23 | E-GEOD-42913 | biostudies-arrayexpress
TranscriptomicseIF3a in Urinary Bladder Cancer M-bM-^@M-^S in vivo and in vitro insights
The eukaryotic translation initiation factor (eIF) 3a is described in various tumor entities as potential tumor marker involved in development and progression of cancer. eIF3a is the largest subunit of the eIF3 complex, a key functional entity in 80S establishment and translation initiation. We hypo...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-45636 | biostudies-arrayexpress
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