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Genome stability relies on epigenetic mechanisms that enforce repression of endogenous retroviruses (ERVs). Current evidence suggests that distinct chromatin-based mechanisms repress ERVs in cells of embryonic origin (histone methylation-dominant) versus more differentiated cells (DNA methylation-do...
ORGANISM(S): Mus musculus 
The integration of immunotherapy into neoadjuvant treatment for triple negative breast cancer (TNBC) has improved outcomes in some patients. Pre-clinical investigation of immunotherapy resistance in the aggressive 4T1 TNBC model has been hampered by a lack of known tumor-specific epitopes. Using pro...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD069588 | Pride
Import and oxidative folding of proteins in the mitochondrial intermembrane space differ among eukaryotic lineages. While opisthokonts such as yeast rely on the receptor and oxidoreductase Mia40 in combination with the Mia40:cytochrome c oxidoreductase Erv, kinetoplastid parasites and other excavate...
ORGANISM(S): Leishmania tarentolae 
2021-07-09 | PXD027121 | Pride
detect ERV interaction proteins in human stem cells
ORGANISM(S): Homo Sapiens 
2022-11-23 | PXD038345 |
Dominant role of DNA methylation over H3K9me3 in ERV silencing during embryonic endoderm development [RNA-Seq]
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