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TranscriptomicsTRIM28 silences endogenous retroviruses in neural progenitor cells
Here we show that in neural progenitor cells (NPCs) TRIM28 silences transcription of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. Derepression of ERVs in Trim28-deficient NPCs was associated with a loss of H3K9me3 and resulted in transcriptional upregulation and reverse transcri...
ORGANISM(S): Mus musculus 
2015-01-07 | E-GEOD-45930 | biostudies-arrayexpress
TranscriptomicsSuv39h-dependent H3K9me3 represses intact retrotransposons in mouse embryonic stem cells
Heterochromatin is required to restrict aberrant expression of retrotransposons, but it remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h-dependent histone H3 lysine 9 trimethylation (H3K9me3) by genome-wide ChIP-sequencing in mouse embryonic stem cells (ESCs). ...
ORGANISM(S): Mus musculus 
2014-06-26 | E-GEOD-57092 | biostudies-arrayexpress
TranscriptomicsDNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements and chimaeric transcripts in mouse ES cells
DNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) play important roles in silencing of genes and retroelements. However, a comprehensive comparison of genes and repetitive elements repressed by these pathways has not been reported. Here we show that in mouse embryonic stem cells (mESC...
ORGANISM(S): Mus musculus 
2011-05-21 | E-GEOD-29413 | biostudies-arrayexpress
GenomicsKAP1 regulates ERVs in differentiated human cells and contributes to innate immune control
KAP1 regulates ERVs in differentiated human cells and contributes to innate immune control
PRJNA473502 | ENA
UnknownH3K9me3 loss and ERVs activation as hallmarks for osteoarthritis progression and knee joint aging.
Not available
S-EPMC11663117 | biostudies-literature
UnknownPhylogenetic Analysis Reveals That ERVs "Die Young" but HERV-H Is Unusually Conserved.
Not available
S-EPMC4905674 | biostudies-literature
TranscriptomicsKAP1 regulates ERVs in differentiated human cells and contributes to innate immune control
Endogenous retroviruses (ERVs) have accumulated in vertebrate genomes and contribute to the complexity of gene regulation. KAP1 represses ERVs during development by its recruitment to their repetitive sequences through KRAB-zinc finger proteins (KZNFs), but little is known about the regulation of ER...
ORGANISM(S): Homo sapiens 
2018-07-15 | GSE114998 | GEO
UnknownUse of endogenous retroviral sequences (ERVs) and structural markers for retroviral phylogenetic inference and taxonomy.
Not available
S-EPMC1224870 | biostudies-literature
UnknownInvestigation of Polymorphisms Induced by the Solo Long Terminal Repeats (Solo-LTRs) in Porcine Endogenous Retroviruses (ERVs).
Not available
S-EPMC11598996 | biostudies-literature
GenomicsTRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells
TRIM28 (KAP1 - KRAB-associated protein 1) is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES) cells. Here, we reveal that an essential impact of this process is the protection of cellular gene expression in early embryos from perturbation by cis-acting activators c...
ORGANISM(S): Mus musculus 
2012-12-04 | E-GEOD-41903 | biostudies-arrayexpress
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