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TranscriptomicsTranscriptional profiles of Campylobacter jejuni macrolide resistant strain JL272 to 4mg/L erythromycin treatment
Erythromycin is the drug of choice to treat campylobacteriosis, but resistance to this antibiotic is rising. The adaptive mechanisms employed by Campylobacter jejuni to erythromycin treatment remain unknown. The aim of this study is to determine the molecular basis underlying CampylobacterM-bM-^@M-^...
ORGANISM(S): Campylobacter jejuni 
2013-10-10 | E-GEOD-43025 | biostudies-arrayexpress
TranscriptomicsPhenotype and expression profile of S. erythraea rifampicin-resistant (rif) mutants affected in erythromycin production
In this study we have used the rifampicin selection as a tool to genetically improve the erythromycin producer Saccharopolyspora erythraea. Two rifampicin-resistant (rif) mutants, rif1 and rif6, have been characterized in more detail. With respect to the parental strain NRRL2338, rif1 (harboring the...
ORGANISM(S): Saccharopolyspora erythraea 
2009-04-12 | E-GEOD-12017 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiles of Campylobacter jejuni NCTC 11168 to 4mg/L erythromycin treatment
Erythromycin is the drug of choice to treat campylobacteriosis, but resistance to this antibiotic is rising. The adaptive mechanisms employed by Campylobacter jejuni to erythromycin treatment remain unknown. The aim of this study is to determine the molecular basis underlying CampylobacterM-bM-^@M-^...
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 
2013-10-10 | E-GEOD-43023 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiles of Campylobacter jejuni NCTC 11168 to 0.125mg/L erythromycin treatment
Erythromycin is the drug of choice to treat campylobacteriosis, but resistance to this antibiotic is rising. The adaptive mechanisms employed by Campylobacter jejuni to erythromycin treatment remain unknown. The aim of this study is to determine the molecular basis underlying CampylobacterM-bM-^@M-^...
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 
2013-10-10 | E-GEOD-43024 | biostudies-arrayexpress
TranscriptomicsComparative Genomics Reveals New Molecular targets for Accelerated Improvement of Erythromycin-producing Strains
Information about molecular mechanisms underlying improvement of antibiotic-producing microorganisms with traditional mutation and screening approach is largely missing. This information is essential to develop rational approaches to strain improvement. In this study by using comparative genomic ana...
ORGANISM(S): Saccharopolyspora erythraea 
2012-05-23 | E-GEOD-30600 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of wild type and erythromycin-producing strain of S. erythraea
Erythromycin is a medically important antibiotic, biosynthesized by the actinomycete Saccharopolyspora erythraea. We used transcriptomic approach to compare whole genome expression in erythromycin high-producing strain, compared to the wild type S. erythraea strain in four stages of fermentation. 2 ...
ORGANISM(S): Saccharopolyspora erythraea 
2016-06-22 | E-GEOD-65007 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiles of Campylobacter jejuni NCTC 11168 and JL272 to erythromycin treatment
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Campylobacter jejuni 
2013-10-10 | E-GEOD-43026 | biostudies-arrayexpress
TranscriptomicsE.coli MG1655M-NM-^T6/pCA24N-dinJ treated with erythromycin vs. MG1655M-NM-^T6/pCA24N
Antitoxins are becoming recognized as proteins that regulate more than their own synthesis; for example, we found previously that antitoxin MqsA represses the gene encoding the stationary phase sigma factor RpoS. Here, we investigated the physiological role of antitoxin DinJ of the DinJ/YafQ toxin/a...
ORGANISM(S): Escherichia coli 
2012-07-08 | E-GEOD-30692 | biostudies-arrayexpress
TranscriptomicsMeta-transcriptomic analysis of the response of river biofilms to pharmaceutical products using anonymous DNA microarray
Low concentrations of pharmaceutical compounds were shown to induce transcriptional responses in isolated microorganisms, which could have consequences on ecosystem dynamics. In order to test if these transcriptional responses could also be observed in complex river microbial communities, biofilm re...
ORGANISM(S): environmental samples 
2010-07-06 | E-GEOD-20501 | biostudies-arrayexpress
ProteomicsLabel-free quantitative proteomics reveals synergistic mechanism of a new erythromycin derivative and oxacillin against methcillin-resistant S. aureus
Methicillin-resistant Staphylococcus aureus (MRSA) remains a global health threat with an over 14% fatality rate, in case of invasive infection, in 2011. Multi-drug resistance is the main reason for the failure of therapy. Use of antimicrobial drug combinations with synergistic effect is increasingl...
ORGANISM(S): Staphylococcus aureus 
2022-03-01 | PXD001494 | Pride
Key words: synergistic effect Label-free quantitative proteomics Oxacillin， methicillin-resistant s. aureus Erythromycin derivative 
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