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ProteomicsSteric Repulsion Counteracts ER-to-Lipid Droplet Protein Movement
Lipid droplets (LDs) are organelles with a neutral lipid core surrounded by a phospholipid monolayer continuous with the endoplasmic reticulum’s (ER) cytosolic leaflet. LDs' dynamics and function relate closely to their constantly remodeling proteome composition. Key proteins relocate from the ER to...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD064671 | Pride
Lc-msms 
ProteomicsSteric Repulsion Counteracts ER-to-Lipid Droplet Protein Movement
Lipid droplets (LDs) are organelles with a neutral lipid core surrounded by a phospholipid monolayer continuous with the endoplasmic reticulum’s (ER) cytosolic leaflet. LDs' dynamics and function relate closely to their constantly remodeling proteome composition. Key proteins relocate from the ER to...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD064674 | Pride
Lc-ms/ms 
MetabolomicsShotgun lipidomics of HeLa whole-cell lysates and lysosomes following LLOMe treatment

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...

2026-07-03 | MTBLS14737 | MetaboLights
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