Sort   by:  
 Page size 
MetabolomicsUntargeted Metabolomics of Mouse Platelet Pellets by LC-MS/MS
In this study, platelet pellets were isolated from mouse peripheral blood through gradient centrifugation to obtain high-purity platelet samples. Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based untargeted metabolomics was performed to comprehensively profile the global metabolic chan...
2026-08-04 | MTBLS15244 | MetaboLights
MetabolomicsLC-MS/MS Quantification of Nuclear α-KG in NSCLC
This study contains targeted LC-MS/MS quantification of α-ketoglutarate (α-KG) in NSCLC cells using 13C-labeled α-KG internal standard. Nuclear α-KG levels were measured in A549, A549/DTX, PC9, and PC9/OR cells. In addition, nuclear α-KG was quantified in GLUD1-overexpressing A549 cells and GLUD1-kn...
2026-07-21 | MTBLS15115 | MetaboLights
MetabolomicsStreamlining LC-MS/MS Data Analysis in R with Open-Source *xcms* and *RforMassSpectrometry*: An End-to-End Workflow

Despite untargeted LC-MS/MS data being a powerful approach for large-scale metabolomics analysis, a significant challenge in the field lies in the reproducible and efficient analysis of such data, in particular. The power of R-based analysis workflows lies in their high customizability and adapta...

2024-08-26 | MTBLS8735 | MetaboLights
MetabolomicsLC-MS/MS metabolomics unravels the resistant phenotype of carbapenemase-producing Enterobacteriaceae

Introduction: The degree of antimicrobial resistance demonstrated by carbapenemase-producing Enterobacteriaceae (CPE) represents a growing public health challenge. Conventional methods for detecting CPE involve culture-based techniques with lengthy incubation steps. There is a ne...

2025-08-04 | MTBLS10129 | MetaboLights
MetabolomicsHigh-Throughput Detection of an Alkaloidal Plant Metabolome in Plant Extracts Using LC-ESI-QTOF-MS.
Plant alkaloids represent a diverse group of nitrogen-containing natural products. These compounds are considered valuable in drug discovery and development. High-throughput identification of such plant secondary metabolites in complex plant extracts is essential for drug discovery, lead optimizatio...
2023-12-12 | MTBLS2914 | MetaboLights
MetabolomicsLC-MS/MS-based targeted metabolomics profiling of central carbon metabolites in Candida albicans SC5314 under control and treatment conditions
Targeted LC-MS/MS metabolomics was performed to profile central carbon and related metabolites in Candida albicans SC5314. Six samples from control and treatment groups were analyzed using UPLC-QTRAP 6500+ in scheduled MRM mode. Data were quantified with MultiQuant and analyzed using PCA, OPLS-DA, d...
2026-07-08 | MTBLS14973 | MetaboLights
MetabolomicsTargeted LC-MS/MS metabolomics of in vitro cultured Rothia mucilaginosa supernatant (tryptophan and short-chain fatty acid panels)
Targeted LC-MS/MS (MRM) metabolomics of in vitro cultured Rothia mucilaginosa:a tryptophan-pathway panel and a short-chain fatty acid panel comparing culture supernatant with medium controls. Raw mzML files are deposited.
2026-10-06 | MTBLS15044 | MetaboLights
MetabolomicsLC-MS/MS targeted analysis of ferroptosis-associated phospholipid peroxidation in KIF11-depleted HRECs

Human retinal vascular endothelial cells (HRECs) were transfected with lentivirus encoding either KIF11-targeting shRNA or a non-targeting control. KIF11-depleted and control cells were then subjected to lipid extraction followed by LC–MS/MS–based targeted analysis of ferroptosis-associated phosp...

2026-02-13 | MTBLS12912 | MetaboLights
MetabolomicsHigh-resolution LC-MS/MS lipidomics characterization of wild-type and ATG7-deficient mouse renal proximal tubule cells
This study provides an untargeted lipidomics investigation of ATG7-deficient (cKO) mouse renal proximal tubule cells compared to wild-type (WT) controls to evaluate lipidomic alterations associated with autophagy deficiency. Lipids were extracted from cell culture wells using a single-phase isopropa...
2026-09-30 | MTBLS15861 | MetaboLights
UnknownLC-ESI-MS/MS Simultaneous Analysis Method Coupled with Cation-Exchange Solid-Phase Extraction for Determination of Pyrrolizidine Alkaloids on Five Kinds of Herbal Medicines.
Not available
S-EPMC8665765 | biostudies-literature
Sort   by:  
 Page size