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TranscriptomicsTherapeutic potential of a novel HSP90 Inhibitor, NXD30001, for Neurofibromatosis type 2
Purpose: The growth and survival of NF2-deficient cells are enhanced by the activation of multiple signaling pathways including ErbB2/IGF-1R/Met, PI3K/Akt, and Ras/Raf/Mek/Erk1/2. The ubiquitously expressed chaperone protein HSP90 is known to be essential for the stabilization of these signaling mol...
ORGANISM(S): Mus musculus 
2013-06-06 | E-GEOD-40187 | biostudies-arrayexpress
TranscriptomicsU87MG Decoded: The Genomic Sequence of a Cytogenetically Aberrant Human Cancer Cell Line
U87MG is a commonly studied grade IV glioma cell line that has been analyzed in at least 1,700 publications over four decades. In order to comprehensively characterize the genome of this cell line and to serve as a model of broad cancer genome sequencing, we have generated greater than 30x genomic s...
ORGANISM(S): Homo sapiens 
2010-01-24 | E-GEOD-19986 | biostudies-arrayexpress
UnknownElucidating mechanistic insights into drug action for atopic dermatitis: a systems biology approach.
Not available
S-EPMC5803917 | biostudies-literature
GenomicsEsophageal progenitor cell plasticity a 3D organotypic model of epithelial regeneration [scATAC-seq]
Esophageal progenitor cell plasticity a 3D organotypic model of epithelial regeneration [scATAC-seq]
PRJNA1295391 | ENA
TranscriptomicsMonocyte Transmigration
We investigated the hypothesis that transmigration drives monocyte transcriptional changes. Using Agilent Whole Human Genome Microarrays, we identified over 600 differentially expressed genes (2x, p<0.05) in freshly isolated human monocytes following 1.5 h of transmigration across IL1beta-stimulate...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-14027 | biostudies-arrayexpress
UnknownGenome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus.
Not available
S-EPMC4102322 | biostudies-literature
TranscriptomicsFeedback regulation of cholesterol metabolism by LeXis, a lipid-responsive non-coding RNA
Abstract: The LXR and SREBP transcription factors are key regulators of cellular and systemic cholesterol homeostasis. The molecular mechanisms that integrate these pathways are incompletely understood. Here we show that ligand activation of LXRs in liver not only promotes cholesterol efflux, but al...
ORGANISM(S): Mus musculus 
2016-02-10 | E-GEOD-77793 | biostudies-arrayexpress
UnknownLong Single-Molecule Reads Can Resolve the Complexity of the Influenza Virus Composed of Rare, Closely Related Mutant Variants.
Not available
S-EPMC5467126 | biostudies-literature
UnknownLeveraging ancestry to improve causal variant identification in exome sequencing for monogenic disorders.
Not available
S-EPMC4795218 | biostudies-literature
TranscriptomicsAplysia pleural Ganglia 1 Hour After Long-Term Sensitization Training
We used a custom-designed microarray and qPCR to characterize the rapid transcriptional response to long-term sensitization training in the marine mollusk Aplysia californica. Aplysia were exposed to repeated noxious shocks to one side of the body (4 ten-second shocks at 90mA, 30 min ISI), a proced...
ORGANISM(S): Aplysia californica 
2014-05-08 | E-GEOD-57458 | biostudies-arrayexpress
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