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TranscriptomicsWhole transcriptome profiling of Esophageal adenocarcinoma and Barrett's
RNA-seq was performed on esophageal adenocarcinoma (EAC), Barrett's without dysplasia, Barrett's with low-grade dysplasia (LGD) and normal squamous esophagus tissue to find early alterations in the transcriptome level turning Barrett's dysplastic.
ORGANISM(S): Homo sapiens 
2017-07-23 | E-MTAB-4054 | biostudies-arrayexpress
TranscriptomicsRobust prognostic biomarkers for EAC identified by systems-level characterization of tumor transcriptome
Despite continual efforts to rationalize a prognostic stratification of patients with esophageal adenocarcinoma (EAC) before treatment, current staging system only shows limited success owing to the lack of molecular and genetic markers that reflect prognostic features of the tumor. To develop molec...
ORGANISM(S): Homo sapiens 
2011-01-04 | E-GEOD-13898 | biostudies-arrayexpress
TranscriptomicsProcessed small RNA sequencing data of healthy and disease tissue samples from patients with esophageal adenocarcinoma or precursor lesions
In the past decades, the incidence of esophageal adenocarcinoma has increased dramatically in Western populations. Better understanding of disease etiology along with the identification of novel prognostic and predictive biomarkers are urgently needed to improve the dismal survival probabilities. He...
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-10003 | biostudies-arrayexpress
MetabolomicsDesorption electrospray ionisation mass spectrometry imaging of esophageal lymph mode metastases
Lymph node metastases (LNM) and primary tumour samples were analysed using desorption electrospray ionisation mass spectrometry imaging (DESI MSI). Current assessment of LNM depends on subjective histopathological assessment, whereas analysis by DESI MSI permits an entirely objective assessment. The...
2017-01-10 | MTBLS385 | MetaboLights
TranscriptomicsLong Noncoding RNA HNF1A-AS1 Regulates Proliferation and Migration in Esophageal Adenocarcinoma Cells
Objectives: Long non-coding RNAs (lncRNAs) have been shown to play important roles in the development and progression of cancer. However, functional lncRNAs and their downstream mechanisms are largely unknown in the molecular pathogenesis of esophageal adenocarcinoma (EAC) and its progression. Desig...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-48240 | biostudies-arrayexpress
TranscriptomicsIntegrated analysis of genome-wide copy number and matched expression data reveals novel genes in esophageal adenocarcinoma
The incidence of esophageal and junctional adenocarcinoma has increased 6-fold in the west in the last 30 years and 5 year survival remains <14%. We aimed to characterize genome-wide aberrations in esophageal adenocarcinoma to further understand disease pathogenesis and ultimately identify groups wi...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-25201 | biostudies-arrayexpress
TranscriptomicsPaired non-cancerous and cancerous miRNA expression of esophageal adenocarcinoma and squamous cell carcinoma patients
Identifying biomarkers predictive for early esophageal cancer detection is critical considering the dismal survival rates. We investigated the involvement of microRNAs (miRNAs), their utility as biomarkers, and their association with survival in esophageal cancer, including Barrett’s associated and...
ORGANISM(S): Homo sapiens 
2010-07-09 | E-GEOD-13937 | biostudies-arrayexpress
ProteomicsMulti-omic analysis of Esophageal Adenocarcinoma uncovers candidate therapeutic targets and cancer-selective post-transcriptional regulation
Efforts to address the poor prognosis associated with esophageal adenocarcinoma (EAC) have been hampered by a lack of biomarkers to identify early disease and therapeutic targets. Despite extensive efforts to understand the somatic mutations associated with EAC over the past decade, a gap remains in...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD042792 | Pride
Esophageal adenocarcinoma 
TranscriptomicsBile acids promote adenocarcinoma in a novel transgenic mouse model of BarrettM-bM-^@M-^Ys esophagus
Esophageal adenocarcinoma (EAC) has the fastest increase of any cancer in the US and Europe, and arises in the setting of BarrettM-bM-^@M-^Ys esophagus (BE), defined by replacement of normal squamous epithelium with columnar intestinal-like epithelium. BE is thought to result from chronic esophagea...
ORGANISM(S): Mus musculus 
2011-01-31 | E-GEOD-24931 | biostudies-arrayexpress
ProteomicsSerum glycoprotein biomarker discovery and qualification pipeline reveals novel diagnostic biomarkers for esophageal adenocarcinoma
The aim of this project is to identify circulatory diagnostic glycoprotein biomarkers for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). Serum samples from healthy, BE and EAC patients were screened using LeMBA-LC-MS/MS-GlycoSelector pipeline as described in the manuscript.
ORGANISM(S): Homo sapiens (Human) 
2015-09-25 | PXD002442 | Pride
Barrett's esophagus (be) Esophageal adenocarcinoma (eac) Biomarker Glycoprotein Lectin 
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