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ProteomicsTargeting kinome reprogramming in ESR1 fusion-driven metastatic breast cancer
Transcriptionally active ESR1 fusions promote endocrine therapy (ET)-resistant growth and metastasis of estrogen receptor-alpha positive (ERα+) breast cancer. Currently, there are no targeted treatment options for tumors harboring active fusions because the ESR1 ligand binding domain (LBD) has been ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD033339 | Pride
Breast cancer Esr1 fusion Kinase 
ProteomicsEstrogen Receptor Mutant Coregulator
Biotinylated 4xERE-containing DNA immobilized on streptavidin beads used to pulldown proteins recruited by unliganded WT ER-alpha versus Y537S, D538G, or ESR1-YAP1 fusion proteins from HeLa S3 human cell nuclear extracts.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-02-08 | MSV000080536 | MassIVE
TranscriptomicsT47D cell line transfected with various ESR1 fusion genes (or with estrogen treatment), vs. YFP transfection alone
Gene expression profiling of the downstream transcriptional changes induced by ESR1 fusion genes observed in human breast tumors resistant to hormone therapy Experimental T47D cells stably expressing ESR1 fusion genes (or T47D cells treated with estradiol) vs. T47D cells expressing YFP
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-69774 | biostudies-arrayexpress
ProteomicsTargeting kinome reprogramming in ESR1 fusion-driven breast cancer
Multiplexed, deep-scale LC-MSMS analysis for proteome and phosphoproteome expression profile and the targeted LC-MSMS analysis for kinases in enriched kinome of the ER+ breast cancer patient-derived xenograft tumors.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-10-24 | PXD036644 | Pride
Lc-msms Esr1 fusion Breast cancer Breast cancer patient-derived xenograft (pdx) tumor Proteome Phosphoproteome 
UnknownRecurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer.
Not available
S-EPMC5913625 | biostudies-literature
UnknownThe prognostic and predictive value of ESR1 fusion gene transcripts in primary breast cancer.
Not available
S-EPMC8840267 | biostudies-literature
TranscriptomicsT47D cell line transfected with various ESR1 fusion genes (or with estrogen treatment), vs. YFP transfection alone
Gene expression profiling of the downstream transcriptional changes induced by ESR1 fusion genes observed in human breast tumors resistant to hormone therapy
ORGANISM(S): Homo sapiens 
2015-06-12 | GSE69774 | GEO
GenomicsTranscriptional properties of estrogen receptor fusion genes.
Transcriptional properties of estrogen receptor fusion genes.
PRJNA477539 | ENA
UnknownElucidation of Novel Therapeutic Targets for Breast Cancer with ESR1-CCDC170 Fusion.
Not available
S-EPMC7913953 | biostudies-literature
GenomicsHomo sapiens
T47D cell line transfected with various ESR1 fusion genes (or with estrogen treatment), vs. YFP transfection alone
PRJNA286743 | ENA
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