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GenomicsThe DNA methylomes of a newborn and a centenarian
We have developed Whole Genome Bisulfite Sequencing (WGBS) of a newborn and a centenarian to address the epigenetic drifts in human aging, which might be an alternative pathway to explain the age-associated alterations. In addition, we have analyzed the methylome of a middle-age donor (26 years). Ex...
ORGANISM(S): Homo sapiens 
2012-06-13 | E-GEOD-31263 | biostudies-arrayexpress
TranscriptomicsGenome-wide CpG methylation during osteogenic and myogenic differentiation from adipose- derived stem cells.
In the current study, we have performed a high-throughput CpG methylation analysis of well characterized and defined populations of human adipose-derived stem cells (hASCs) before and after in vitro induction of osteogenic and myogenic differentiation that allows identifying DNA methylation- regulat...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-33896 | biostudies-arrayexpress
TranscriptomicsEpigenetically Silenced Genes Found Using Methylated DNA Immunoprecipitation in Colon Cancer Cells Deficient in DNMTs
CpG island promoter hypermethylation of tumor suppressor genes is a common hallmark of human cancer, and new large-scale epigenomic technologies might be useful in our attempts to define the complete DNA hypermethylome of tumor cells. Here we report a functional search for hypermethylated CpG island...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-9267 | biostudies-arrayexpress
TranscriptomicsThe DNA Methylomes of a Newborn and a Centenarian
Examination of two DNA methylomes at the most extreme points of their lives to see differences that might contribute to explain the aged phenotype We have performed Whole Genome Bisulfite Sequencing (WGBS) and methylation array technology of newborn and a centenarian samples to address the Epigeneti...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-31438 | biostudies-arrayexpress
TranscriptomicsDNA Methylation Biomarkers for Noninvasive Diagnosis of Colorectal Cancer
DNA methylation in colorectal cancer diagnosis. The Illumina GoldenGate Methylation Cancer Panel I was used to select a set of candidates markers informative of colorectal cancer diagnosis from 807 cancer-related genes. In the discovery phase, tumor tissue and paired adjacent normal mucosa from 92 c...
ORGANISM(S): Homo sapiens 
2013-05-27 | E-GEOD-43369 | biostudies-arrayexpress
TranscriptomicsDNA methylation differences between Newborns and Nonagenarians [PBMNC]
Human aging implies many phenotypic modifications and an increased susceptibility to many common diseases, phenomena that cannot be fully explained by the constrained genetic setting. An alternative pathway that could explain the age-associated alterations is epigenetic drifts. To address this issue...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-33233 | biostudies-arrayexpress
TranscriptomicsDNA methylomes of Newborns and Nonagenarians
DNA methylation differences between Newborns and Nonagenarians The study aimed to compare the DNA methylation differences between newborns and nonagenarians using methylation array technology (450K, Illumina). The identified differently methylated CpG were further analyzed for their presence in dise...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-30870 | biostudies-arrayexpress
GenomicsComparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues
In our study we applied a genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially methylated regions in 24 tumor and matched normal colon samples. In total, 2687 frequently hypermethylated and 468 frequently hypomethylated regions were identified, which include potent...
ORGANISM(S): Homo sapiens 
2012-10-26 | E-GEOD-39068 | biostudies-arrayexpress
UnknownRemodeling of the m6A RNA landscape in the conversion of acute lymphoblastic leukemia cells to macrophages.
Not available
S-EPMC9343246 | biostudies-literature
GenomicsGenome-wide DNA methylation aberrations in human atherosclerosis (sequencing)
Epigenetics may help understanding the molecular mechanisms of atherosclerosis as genetic predisposition explains only part of cardiovascular disease risk. In particular, DNA methylation, a reversible and highly regulative DNA modification could contribute to disease onset and progression as it func...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-46327 | biostudies-arrayexpress
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