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MetabolomicsExploring the effect of estrogen on Candida albicans hyphal cell wall glycans and ergosterol synthesis
Increased levels of 17-β estradiol (E2) due to pregnancy in young women or to hormonal replacement therapy in postmenopausal women have long been associated with an increased risk of yeast infections. Nevertheless, the effect underlying the role of E2 in Candida albicans infections is not wel...
2025-09-11 | MTBLS5821 | MetaboLights
GenomicsChIP-Seq of human MCF-7 cells with ER-alpha and ER-beta anitbodies following estrogen treatment
We performed chromatin immunoprecipitation (ChIP) with overnight with antibodies against the C-terminus (HC-20, from Santa Cruz Biotechnology, Europe) or the N-terminus (anti-Estrogen Receptor 18-32, from SigmaAldrich, Italy) of human ER-alpha with or without estrogen treatment for 45 minutes on TAP...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-MTAB-345 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cancer cell line MCF-7 - estrogen effects where MCF7 is co-expressing ERa and ERb
Two subtypes of the estrogen receptor, ERalpha and ERbeta, mediate the actions of estrogens, and the majority of human breast tumors contain both ERalpha and ERbeta. To examine the possible interactions and modulatory effects of ERbeta on ERalpha activity, we have used adenoviral gene delivery to pr...
ORGANISM(S): Homo sapiens 
2009-04-24 | E-GEOD-4006 | biostudies-arrayexpress
ProteomicsIdentification of cytoplasmic proteins interacting with unliganded estrogen receptor α and β- in human breast cancer cells
Estrogen Receptor subtypes (ERα and ERβ) are transcription factors sharing similar structure, however, they often perform opposite roles in breast cancer’s cell proliferation and tumor progression. Besides the well-characterized genomic actions of ERs upon ligand binding, rapid non-genomic cytoplasm...
ORGANISM(S): Homo sapiens (Human) 
2015-03-11 | PXD001202 | Pride
Estrogen receptor Tap-tag Lc-ms/ms 
MetabolomicsEstrogen receptor a deficiency in cardiac myocytes reprograms heart-derived extracellular vesicle proteome and induces obesity in female mice (Part 2)
Not available
ORGANISM(S): Mus musculus 
ST002228 | MetabolomicsWorkbench
ProteomicsStromal Interaction Molecule 1 Maintains Beta Cell Identity and Function in Female Mice through Preservation of G Protein-Coupled Estrogen Receptor 1 Signaling
Loss of pancreatic Beta cell mass, identity, and function contribute to the development of diabetes. Here, we show that the endoplasmic reticulum (ER) calcium sensor, stromal interaction molecule 1 (STIM1), is critical for the maintenance of Beta cell function in female mice. When mice with Beta cel...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2022-07-20 | MSV000089927 | MassIVE
TranscriptomicsTranscription profiling of rat peripheral blood leukocytes treated with the estrogen receptor agonists estradiol, PPT and DPN to investigates the functional roles of estrogen receptor alpha and beta
This experiment investigates the functional roles of estrogen receptor alpha and beta in peripheral blood leukocytes by using selective estrogen receptor agonists. The agonists that are used are estradiol (E2), the selective ER-alpha agonist PPT (4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphen...
ORGANISM(S): Rattus norvegicus 
2007-05-30 | E-TABM-269 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse vascular tissue from estrogen receptor alpha knockout (ERaKO) and estrogen receptor beta knockout (ERbKO) mice and vs. wild type control, all ovarioectomized treated with 17beta-estradiol pellets vs. placebo
Estrogen plays an important role in the regulation of vascular tone and in the pathophysiology of cardiovascular disease. Physiological effects of estrogen are mediated through estrogen receptors alpha (ERalpha) and beta (ERbeta), which are both expressed in vascular smooth muscle and endothelial ce...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9371 | biostudies-arrayexpress
no omics definedTranscription profiling of breast cancer cells with TET-OFF regulated ERb expression treated with estradiol or ICI, an estrogen receptor antagonist
Assess the full impact of estrogen receptor beta on transcription by a full transcriptome analysis of ERa and ERb-mediated gene regulation in T47D breast cancer cell line with TET-OFF regulated ERb expression.
ORGANISM(S): Homo sapiens 
2007-12-17 | E-MEXP-969 | biostudies-arrayexpress
ProteomicsUnliganded Estrogen Receptor beta (ERβ) interactome before and after RNAse treatment in human breast cancer cells nuclei.
The Estrogen Receptor beta (ERβ), is a member of the nuclear receptor superfamily of trancriptional regulators, with oncosuppressive activities, antagonizing hormone-induced carcinogenesis and inhibiting growth and oncogenic functions in breast cancers (BCs). It is able to exert specific biological ...
ORGANISM(S): Homo sapiens (Human) 
2017-12-19 | PXD006720 | Pride
Affinity purification  mass spectrometry  estrogen receptor beta 
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