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MetabolomicsP53 dependent hypusination of eIF5A affect mitochondrial translation and senescence immune surveillance
Cellular senescence is characterized by a permanent growth arrest and is associated with tissue aging and cancer. Senescent cells secrete a number of different cytokines referred to as the senescence-associated secretory phenotype (SASP), which impacts the surrounding tissue and immune response. Her...
2024-08-14 | MTBLS10690 | MetaboLights
MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
ProteomicsDeoxyhypusine synthase (DHPS) mutations alter the post-translational modification of eukaryotic initiation factor 5A (eIF5A) resulting in impaired human and mouse neural homeostasis
DHPS deficiency is a rare genetic disease caused by biallelic hypomorphic variants in the Deoxyhypusine synthase (DHPS) gene. The DHPS enzyme functions in mRNA translation by catalyzing the post-translational modification, and therefore activation, of the eukaryotic initiation factor 5A (eIF5A). The...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-06-06 | MSV000092112 | MassIVE
ProteomicsA translational regulatory mechanism mediated by hypusinated eukaryotic initiation factor 5A facilitates beta cell identity and function
As professional secretory cells, beta cells require adaptable mRNA translation to facilitate a rapid synthesis of proteins, including insulin, in response to changing metabolic cues. Specialized mRNA translation programs are essential drivers of cellular development and differentiation. However, in ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-10-12 | MSV000093089 | MassIVE
UnknownPhosphorylation of maize eukaryotic translation initiation factor 5A (eIF5A) by casein kinase 2: identification of phosphorylated residue and influence on intracellular localization of eIF5A.
Not available
S-EPMC2825417 | biostudies-literature
ProteomicsTAP-ERK2-K52R MS analysis of 1D gel bands
MS analysis of 1D gel bands from TAP-ERK2-K52R immunoprecipitation experiments
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088047 | MassIVE
UnknownInhibition of Eukaryotic Translation Initiation Factor 5A (eIF5A) Hypusination Suppress p53 Translation and Alters the Association of eIF5A to the Ribosomes.
Not available
S-EPMC7369855 | biostudies-literature
UnknownEukaryotic translation initiation factor (eIF) 5A stimulates protein synthesis in Saccharomyces cerevisiae.
Not available
S-EPMC3081013 | biostudies-literature
UnknownDeoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing Proteins.
Not available
S-EPMC4528157 | biostudies-literature
ProteomicsEukaryotic translation initiation factor 5A regulates autophagy via translation of ATG3
Autophagy is an essential catabolic process responsible for recycling of intracellular material and preserving cellular fidelity. Key to the autophagy pathway is the ubiquitin-like conjugation system mediating lipidation of Atg8 proteins and their anchoring to autophagosomal membranes. While regulat...
ORGANISM(S): Homo sapiens (Human) 
2018-04-27 | PXD008874 | Pride
Newly synthesized proteins Lc-ms Eif5a 
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